Paul Keim
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Explore the profile of Paul Keim including associated specialties, affiliations and a list of published articles.
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Articles
267
Citations
16983
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Recent Articles
1.
Busch J, Kaestli M, Mayo M, Roe C, Vazquez A, Choy J, et al.
PLoS Negl Trop Dis
. 2024 Dec;
18(12):e0012683.
PMID: 39700310
Background: Burkholderia pseudomallei, causative agent of melioidosis, is a One Health concern as it is acquired directly from soil and water and causes disease in humans and agricultural and wild...
2.
Mead H, Valentine M, Yin H, Thompson Iii G, Keim P, Engelthaler D, et al.
Microbiol Spectr
. 2024 Aug;
12(10):e0100824.
PMID: 39162534
Importance: Developing new drugs, especially for regional orphan diseases, such as Valley Fever, is a slow and costly endeavor. However, there is a wealth of FDA-approved drugs available for repurposing,...
3.
Pearson T, Furstenau T, Wood C, Rigas V, Sahl J, Maltinsky S, et al.
bioRxiv
. 2024 Jul;
PMID: 38948873
Genomic diversity in a pathogen population is the foundation for evolution and adaptations in virulence, drug resistance, pathogenesis, and immune evasion. Characterizing, analyzing, and understanding population-level diversity is also essential...
4.
Taylor A, Yahara K, Pascoe B, Ko S, Mageiros L, Mourkas E, et al.
mBio
. 2024 Apr;
15(6):e0058124.
PMID: 38683013
Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core...
5.
Williamson C, Vazquez A, Nunnally A, Kyger K, Fofanov V, Furstenau T, et al.
Microbiol Spectr
. 2024 Apr;
12(6):e0413923.
PMID: 38651881
is a diverse pathogen, causing a range of disease in humans, from self-limiting diarrhea to urinary tract infections (UTIs). Uropathogenic (UPEC) is the most frequently observed uropathogen in UTIs, a...
6.
Andrianaivoarimanana V, Savin C, Birdsell D, Vogler A, Le Guern A, Rahajandraibe S, et al.
Emerg Infect Dis
. 2024 Jan;
30(2):289-298.
PMID: 38270131
Pneumonic plague (PP) is characterized by high infection rate, person-to-person transmission, and rapid progression to severe disease. In 2017, a PP epidemic occurred in 2 Madagascar urban areas, Antananarivo and...
7.
Williamson C, Roe C, Terriquez J, Hornstra H, Lucero S, Nunnally A, et al.
Microb Genom
. 2023 Jun;
9(6).
PMID: 37347682
Although infections caused by have historically been attributed to hospital acquisition, growing evidence supports the role of community acquisition in infection (CDI). Symptoms of CDI can range from mild, self-resolving...
8.
Hall C, Somprasong N, Hagen J, Nottingham R, Sahl J, Webb J, et al.
Antimicrob Agents Chemother
. 2023 May;
67(6):e0017123.
PMID: 37133377
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by β-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with resistance found...
9.
Hall C, Stone N, Martz M, Hutton S, Santana-Propper E, Versluis L, et al.
Emerg Infect Dis
. 2023 Feb;
29(3):618-621.
PMID: 36823515
Burkholderia thailandensis, an opportunistic pathogen found in the environment, is a bacterium closely related to B. pseudomallei, the cause of melioidosis. Human B. thailandensis infections are uncommon. We isolated B....
10.
Celona K, Shannon A, Sonderegger D, Yi J, Monroy F, Allender C, et al.
PLoS Negl Trop Dis
. 2023 Feb;
17(2):e0011067.
PMID: 36753522
Background: Melioidosis is a disease caused by the bacterium Burkholderia pseudomallei, infecting humans and non-human primates (NHP) through contaminated soil or water. World-wide there are an estimated 165,000 human melioidosis...