Paul J Russell
Overview
Explore the profile of Paul J Russell including associated specialties, affiliations and a list of published articles.
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18
Citations
162
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Recent Articles
1.
Grove D, Russell P, Kearse M
Wiley Interdiscip Rev RNA
. 2024 Mar;
15(2):e1833.
PMID: 38433101
Selection of the correct start codon is critical for high-fidelity protein synthesis. In eukaryotes, this is typically governed by a multitude of initiation factors (eIFs), including eIF2·GTP that directly delivers...
2.
Russell P, Slivka J, Boyle E, Burghes A, Kearse M
RNA
. 2023 Mar;
29(6):735-744.
PMID: 36878710
It is estimated that nearly 50% of mammalian transcripts contain at least one upstream open reading frame (uORF), which are typically one to two orders of magnitude smaller than the...
3.
Neural network activation similarity: a new measure to assist decision making in chemical toxicology
Allen T, Wedlake A, Gelzinyte E, Gong C, Goodman J, Gutsell S, et al.
Chem Sci
. 2021 Jun;
11(28):7335-7348.
PMID: 34123016
Deep learning neural networks, constructed for the prediction of chemical binding at 79 pharmacologically important human biological targets, show extremely high performance on test data (accuracy 92.2 ± 4.2%, MCC...
4.
Wedlake A, Allen T, Goodman J, Gutsell S, Kukic P, Russell P
Chem Res Toxicol
. 2020 Dec;
33(12):3010-3022.
PMID: 33295767
Having a measure of confidence in computational predictions of biological activity from tools is vital when making predictions for new chemicals, for example, in chemical risk assessment. Where predictions of...
5.
Allen T, Nelms M, Edwards S, Goodman J, Gutsell S, Russell P
Environ Sci Technol
. 2020 May;
54(12):7461-7470.
PMID: 32432465
Molecular initiating events (MIEs) are key events in adverse outcome pathways that link molecular chemistry to target biology. As they are based on chemistry, these interactions are excellent targets for...
6.
Wedlake A, Folia M, Piechota S, Allen T, Goodman J, Gutsell S, et al.
Chem Res Toxicol
. 2019 Dec;
33(2):388-401.
PMID: 31850746
A molecular initiating event (MIE) is the gateway to an adverse outcome pathway (AOP), a sequence of events ending in an adverse effect. In silico predictions of MIEs are a...
7.
Rivetti C, Allen T, Brown J, Butler E, Carmichael P, Colbourne J, et al.
Toxicol In Vitro
. 2019 Nov;
62:104692.
PMID: 31669395
There is a growing recognition that application of mechanistic approaches to understand cross-species shared molecular targets and pathway conservation in the context of hazard characterization, provide significant opportunities in risk...
8.
Allen T, Goodman J, Gutsell S, Russell P
Chem Res Toxicol
. 2019 Sep;
33(2):324-332.
PMID: 31517476
The aim of human toxicity risk assessment is to determine a safe dose or exposure to a chemical for humans. This requires an understanding of the exposure of a person...
9.
Sanderson P, Simpson W, Cubberley R, Aleksic M, Gutsell S, Russell P
Toxicol Res (Camb)
. 2018 Aug;
5(1):34-44.
PMID: 30090324
Toxicological risk assessments in the 21 century are increasingly being driven by the Adverse Outcome Pathways (AOP) conceptual framework in which the Molecular Initiating Event (MIE) is of fundamental importance...
10.
Allen T, Goodman J, Gutsell S, Russell P
Toxicol Sci
. 2018 Jul;
165(1):213-223.
PMID: 30020496
Molecular initiating events (MIEs) are important concepts for in silico predictions. They can be used to link chemical characteristics to biological activity through an adverse outcome pathway (AOP). In this...