Andrew J Wedlake
Overview
Explore the profile of Andrew J Wedlake including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
61
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Recent Articles
1.
Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Alberga D, et al.
Environ Health Perspect
. 2021 Oct;
129(10):109001.
PMID: 34647794
No abstract available.
2.
Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Alberga D, et al.
Environ Health Perspect
. 2021 Jul;
129(7):79001.
PMID: 34242083
No abstract available.
3.
Neural network activation similarity: a new measure to assist decision making in chemical toxicology
Allen T, Wedlake A, Gelzinyte E, Gong C, Goodman J, Gutsell S, et al.
Chem Sci
. 2021 Jun;
11(28):7335-7348.
PMID: 34123016
Deep learning neural networks, constructed for the prediction of chemical binding at 79 pharmacologically important human biological targets, show extremely high performance on test data (accuracy 92.2 ± 4.2%, MCC...
4.
Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Alberga D, et al.
Environ Health Perspect
. 2021 Apr;
129(4):47013.
PMID: 33929906
Background: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory...
5.
Wedlake A, Allen T, Goodman J, Gutsell S, Kukic P, Russell P
Chem Res Toxicol
. 2020 Dec;
33(12):3010-3022.
PMID: 33295767
Having a measure of confidence in computational predictions of biological activity from tools is vital when making predictions for new chemicals, for example, in chemical risk assessment. Where predictions of...
6.
Wedlake A, Folia M, Piechota S, Allen T, Goodman J, Gutsell S, et al.
Chem Res Toxicol
. 2019 Dec;
33(2):388-401.
PMID: 31850746
A molecular initiating event (MIE) is the gateway to an adverse outcome pathway (AOP), a sequence of events ending in an adverse effect. In silico predictions of MIEs are a...
7.
Giorio C, Campbell S, Bruschi M, Tampieri F, Barbon A, Toffoletti A, et al.
J Am Chem Soc
. 2017 Feb;
139(11):3999-4008.
PMID: 28201872
Biogenic alkenes, which are among the most abundant volatile organic compounds in the atmosphere, are readily oxidized by ozone. Characterizing the reactivity and kinetics of the first-generation products of these...