Paul J R Barton
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Explore the profile of Paul J R Barton including associated specialties, affiliations and a list of published articles.
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86
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3711
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Recent Articles
1.
Tadros R, Zheng S, Grace C, Jorda P, Francis C, West D, et al.
Nat Genet
. 2025 Feb;
57(3):530-538.
PMID: 39966646
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality with both monogenic and polygenic components. Here, we report results from a large genome-wide association study and multitrait analysis...
2.
Zheng S, Jurgens S, McGurk K, Xu X, Grace C, Theotokis P, et al.
Nat Genet
. 2025 Feb;
57(3):563-571.
PMID: 39966645
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality, with pathogenic variants found in about a third of cases. Large-scale genome-wide association studies (GWAS) demonstrate that common genetic...
3.
Jennings E, Mackay R, Renwick C, Josephs K, Buchan R, Barton P, et al.
Cardiol Young
. 2025 Feb;
:1-8.
PMID: 39910861
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most common indication for a heart transplant. Guidelines are regularly based on studies of adults and applied to...
4.
Zheng S, Henry A, Cannie D, Lee M, Miller D, McGurk K, et al.
Nat Genet
. 2024 Nov;
56(12):2646-2658.
PMID: 39572783
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular...
5.
Sweeney M, OFee K, Villanueva-Hayes C, Rahman E, Lee M, Tam C, et al.
Cardiovasc Res
. 2024 Oct;
120(17):2220-2235.
PMID: 39383190
Aims: Interleukin 11 (IL11) was initially thought important for platelet production, which led to recombinant IL11 being developed as a drug to treat thrombocytopenia. IL11 was later found to be...
6.
Ochoa J, Lalaguna L, Mirelis J, Dominguez F, Gonzalez-Lopez E, Salas C, et al.
Circ Heart Fail
. 2024 Mar;
17(3):e011226.
PMID: 38436102
No abstract available.
7.
McGurk K, Zhang X, Theotokis P, Thomson K, Harper A, Buchan R, et al.
Am J Hum Genet
. 2023 Aug;
110(9):1482-1495.
PMID: 37652022
Understanding the penetrance of pathogenic variants identified as secondary findings (SFs) is of paramount importance with the growing availability of genetic testing. We estimated penetrance through large-scale analyses of individuals...
8.
Sweeney M, OFee K, Villanueva-Hayes C, Rahman E, Lee M, Vanezis K, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37629170
Cardiac fibrosis is a common pathological process in heart disease, representing a therapeutic target. Transforming growth factor β (TGFβ) is the canonical driver of cardiac fibrosis and was recently shown...
9.
Allouba M, Walsh R, Afify A, Hosny M, Halawa S, Galal A, et al.
Eur Heart J
. 2023 Jul;
44(48):5146-5158.
PMID: 37431535
Aims: Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity that is partly explained by the diversity of genetic variants contributing to disease. Accurate interpretation of these variants constitutes a major...
10.
Lota A, Hazebroek M, Theotokis P, Wassall R, Salmi S, Halliday B, et al.
Circulation
. 2022 Sep;
146(15):1123-1134.
PMID: 36154167
Background: Acute myocarditis is an inflammatory condition that may herald the onset of dilated cardiomyopathy (DCM) or arrhythmogenic cardiomyopathy (ACM). We investigated the frequency and clinical consequences of DCM and...