Declan P ORegan
Overview
Explore the profile of Declan P ORegan including associated specialties, affiliations and a list of published articles.
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116
Citations
2641
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Recent Articles
1.
Zhu Y, Armour C, Li B, Pirola S, Salmasi Y, Athanasiou T, et al.
Biomech Model Mechanobiol
. 2025 Mar;
PMID: 40067580
This study aimed to characterize the altered hemodynamics and wall mechanics in ascending thoracic aortic aneurysms (ATAA) by employing fully coupled two-way fluid-structure interaction (FSI) analyses. Our FSI models incorporated...
2.
Tadros R, Zheng S, Grace C, Jorda P, Francis C, West D, et al.
Nat Genet
. 2025 Feb;
57(3):530-538.
PMID: 39966646
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality with both monogenic and polygenic components. Here, we report results from a large genome-wide association study and multitrait analysis...
3.
Zheng S, Jurgens S, McGurk K, Xu X, Grace C, Theotokis P, et al.
Nat Genet
. 2025 Feb;
57(3):563-571.
PMID: 39966645
Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality, with pathogenic variants found in about a third of cases. Large-scale genome-wide association studies (GWAS) demonstrate that common genetic...
4.
Bergan N, Prachee I, Curran L, McGurk K, Lu C, de Marvao A, et al.
Circulation
. 2025 Feb;
151(7):442-459.
PMID: 39895490
Background: Dilated cardiomyopathy (DCM) appears to be diagnosed twice as often in male than in female patients. This could be attributed to underdiagnosis in female patients or sex differences in...
5.
Higher Aircraft Noise Exposure Is Linked to Worse Heart Structure and Function by Cardiovascular MRI
Topriceanu C, Gong X, Shah M, Shiwani H, Eminson K, Atilola G, et al.
J Am Coll Cardiol
. 2025 Jan;
85(5):454-469.
PMID: 39772360
Background: Aircraft noise is a growing concern for communities living near airports. Objectives: This study aimed to explore the impact of aircraft noise on heart structure and function. Methods: Nighttime...
6.
Sau A, Barker J, Pastika L, Sieliwonczyk E, Patlatzoglou K, McGurk K, et al.
JAMA Cardiol
. 2025 Jan;
10(3):214-223.
PMID: 39745684
Importance: Hypertension underpins significant global morbidity and mortality. Early lifestyle intervention and treatment are effective in reducing adverse outcomes. Artificial intelligence-enhanced electrocardiography (AI-ECG) has been shown to identify a broad...
7.
Zheng S, Henry A, Cannie D, Lee M, Miller D, McGurk K, et al.
Nat Genet
. 2024 Nov;
56(12):2646-2658.
PMID: 39572783
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular...
8.
McGurk K, Qiao M, Zheng S, Sau A, Henry A, Ribeiro A, et al.
Nat Cardiovasc Res
. 2024 Nov;
3(12):1503-1515.
PMID: 39567769
Cardiac trabeculae form a network of muscular strands that line the inner surfaces of the heart. Their development depends on multiscale morphogenetic processes and, while highly conserved across vertebrate evolution,...
9.
Sau A, Ribeiro A, McGurk K, Pastika L, Bajaj N, Gurnani M, et al.
Circ Cardiovasc Qual Outcomes
. 2024 Nov;
17(12):e010602.
PMID: 39540287
Background: Subtle, prognostically important ECG features may not be apparent to physicians. In the course of supervised machine learning, thousands of ECG features are identified. These are not limited to...
10.
Zhu Y, Pirola S, Salmasi M, Sasidharan S, Fisichella S, ORegan D, et al.
Cardiovasc Eng Technol
. 2024 Oct;
16(1):52-65.
PMID: 39455477
Purpose: Finite element analysis (FEA) has been used to predict wall stress in ascending thoracic aortic aneurysm (ATAA) in order to evaluate risk of dissection or rupture. Patient-specific FEA requires...