James F Leckman
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Explore the profile of James F Leckman including associated specialties, affiliations and a list of published articles.
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263
Citations
9948
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Recent Articles
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Ravagnani Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, et al.
JCPP Adv
. 2025 Mar;
5(1):e12268.
PMID: 40060001
Background: Understanding the factors that determine distinct courses of anxiety symptoms throughout development will better guide interventions. There are scarce data-driven longitudinal studies, using multi-modal predictors, investigating the chronicity of...
3.
Wang Y, Fasching L, Wu F, Suvakov M, Huttner A, Berretta S, et al.
Biol Psychiatry
. 2025 Feb;
PMID: 39892689
Background: Tourette disorder is characterized by motor hyperactivity and tics that are believed to originate in basal ganglia. Postmortem immunocytochemical analyses previously revealed decreases in cholinergic, parvalbumin, and somatostatin interneurons...
4.
Hein S, Ponguta L, Flores J, Tobon A, Johnson I, Larran J, et al.
Child Psychiatry Hum Dev
. 2024 Nov;
PMID: 39576491
We examined the social and emotional challenges (SEC) of young children and the mental health of their caregivers in areas affected by armed conflict and displacement in Colombia. Anxiety, depression,...
5.
Zhao Q, Hu Y, Yan Y, Song X, Yu J, Wang W, et al.
Phytomedicine
. 2024 May;
129:155686.
PMID: 38759346
Background: Tourette syndrome (TS) represents a neurodevelopmental disorder characterized by an uncertain etiology and influencing factors. Frequently, it co-occurs with conditions such as attention deficit hyperactivity disorder, obsessive-compulsive disorder, and...
6.
Danese A, Martsenkovskyi D, Remberk B, Khalil M, Diggins E, Keiller E, et al.
J Am Acad Child Adolesc Psychiatry
. 2024 May;
64(2):226-248.
PMID: 38735431
Objective: More than 200 million children and adolescents live in countries affected by violent conflict, are likely to have complex mental health needs, and struggle to access traditional mental health...
7.
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, et al.
J Psychiatr Res
. 2024 Apr;
173:387-397.
PMID: 38598877
Introduction: Expert consensus operationalized treatment response and remission in obsessive-compulsive disorder (OCD) as a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) reduction ≥35% and score ≤12 with ≤2 on Clinical Global Impressions Improvement...
8.
Wang Y, Fasching L, Wu F, Huttner A, Berretta S, Roberts R, et al.
bioRxiv
. 2024 Mar;
PMID: 38464084
Tourette syndrome (TS) is a disorder of high-order integration of sensory, motor, and cognitive functions afflicting as many as 1 in 150 children and characterized by motor hyperactivity and tics....
9.
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D
Psychol Med
. 2023 Jul;
53(16):7857-7864.
PMID: 37485677
Background: Comprehensive Behavioral Intervention for Tics (CBIT) is recommended as a first-line treatment for Tourette syndrome in children and adults. While there is strong evidence proving its efficacy, the mechanisms...
10.
Jang Y, Fasching L, Bae T, Tomasini L, Schreiner J, Szekely A, et al.
Nucleic Acids Res
. 2023 Apr;
51(10):e57.
PMID: 37026484
Mosaic mutations can be used to track cell ancestries and reconstruct high-resolution lineage trees during cancer progression and during development, starting from the first cell divisions of the zygote. However,...