Paul J Gresch
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Explore the profile of Paul J Gresch including associated specialties, affiliations and a list of published articles.
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16
Citations
337
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Recent Articles
1.
Stewart A, Mayer F, Gowrishankar R, Davis G, Areal L, Gresch P, et al.
Mol Psychiatry
. 2022 Sep;
27(12):4869-4880.
PMID: 36117213
Virtually all neuropsychiatric disorders display sex differences in prevalence, age of onset, and/or clinical symptomology. Although altered dopamine (DA) signaling is a feature of many of these disorders, sex-dependent mechanisms...
2.
Quinlan M, Krout D, Katamish R, Robson M, Nettesheim C, Gresch P, et al.
ACS Chem Neurosci
. 2019 Jan;
10(7):3249-3260.
PMID: 30668912
The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. In a study of families with multiple individuals diagnosed with autism...
3.
Stewart A, Davis G, Gresch P, Katamish R, Peart R, Rabil M, et al.
Neuropsychopharmacology
. 2018 Dec;
44(5):994-1006.
PMID: 30578419
Dopamine (DA) signaling dysfunction is believed to contribute to multiple neuropsychiatric disorders including attention-deficit/hyperactivity disorder (ADHD). The rare DA transporter (DAT) coding substitution Ala559Val found in subjects with ADHD, bipolar...
4.
Gowrishankar R, Gresch P, Davis G, Katamish R, Riele J, Stewart A, et al.
J Neurosci
. 2018 May;
38(23):5302-5312.
PMID: 29739866
Disruptions of dopamine (DA) signaling contribute to a broad spectrum of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), addiction, bipolar disorder, and schizophrenia. Despite evidence that risk for these disorders...
5.
Simmler L, Anacker A, Levin M, Vaswani N, Gresch P, Nackenoff A, et al.
Br J Pharmacol
. 2017 Jun;
174(16):2716-2738.
PMID: 28585320
Background And Purpose: The psychostimulant cocaine induces complex molecular, cellular and behavioural responses as a consequence of inhibiting presynaptic dopamine, noradrenaline and 5-HT transporters. To elucidate 5-HT transporter (SERT)-specific contributions...
6.
Zhang Z, Shen M, Gresch P, Ghamari-Langroudi M, Rabchevsky A, Emeson R, et al.
EMBO Mol Med
. 2016 Jul;
8(8):878-94.
PMID: 27406820
The serotonin 2C receptor regulates food uptake, and its activity is regulated by alternative pre-mRNA splicing. Alternative exon skipping is predicted to generate a truncated receptor protein isoform, whose existence...
7.
Mergy M, Gowrishankar R, Gresch P, Gantz S, Williams J, Davis G, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(44):E4779-88.
PMID: 25331903
Despite the critical role of the presynaptic dopamine (DA) transporter (DAT, SLC6A3) in DA clearance and psychostimulant responses, evidence that DAT dysfunction supports risk for mental illness is indirect. Recently,...
8.
Saunders C, Siuta M, Robertson S, Davis A, Sauer J, Matthies H, et al.
Neurochem Int
. 2013 Oct;
73:113-121.
PMID: 24090638
The serotonergic system regulates a wide range of behavior, including mood and impulsivity, and its dysregulation has been associated with mood disorders, autism spectrum disorder, and addiction. Diabetes is a...
9.
Thompson B, Jessen T, Henry L, Field J, Gamble K, Gresch P, et al.
Proc Natl Acad Sci U S A
. 2011 Feb;
108(9):3785-90.
PMID: 21282638
Serotonin [i.e., 5-hydroxytryptamine (5-HT)]-targeted antidepressants are in wide use for the treatment of mood disorders, although many patients do not show a response or experience unpleasant side effects. Psychostimulants, such...
10.
Siuta M, Robertson S, Kocalis H, Saunders C, Gresch P, Khatri V, et al.
PLoS Biol
. 2010 Jun;
8(6):e1000393.
PMID: 20543991
The mammalian target of rapamycin (mTOR) complex 2 (mTORC2) is a multimeric signaling unit that phosphorylates protein kinase B/Akt following hormonal and growth factor stimulation. Defective Akt phosphorylation at the...