Paul J Derry
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Explore the profile of Paul J Derry including associated specialties, affiliations and a list of published articles.
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27
Citations
284
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Recent Articles
1.
Vo A, Mouli K, Liopo A, Lorenzi P, Tan L, Wei B, et al.
Nanomaterials (Basel)
. 2024 Dec;
14(24.
PMID: 39728553
Our group has synthesized a pleiotropic synthetic nanozyme redox mediator we term a "pleozyme" that displays multiple enzymatic characteristics, including acting as a superoxide dismutase mimetic, oxidizing NADH to NAD,...
2.
Vo A, Khan U, Liopo A, Mouli K, Olson K, McHugh E, et al.
Nanomaterials (Basel)
. 2024 Dec;
14(24.
PMID: 39728543
Harsh acid oxidation of activated charcoal transforms an insoluble carbon-rich source into water-soluble, disc structures of graphene decorated with multiple oxygen-containing functionalities. We term these pleiotropic nano-enzymes as "pleozymes". A...
3.
Mouli K, Liopo A, Suva L, Olson K, McHugh E, Tour J, et al.
Antioxidants (Basel)
. 2024 Nov;
13(11).
PMID: 39594503
Down syndrome (DS) is a multisystemic disorder that includes accelerated aging caused by trisomy 21. In particular, overexpression of cystathionine-β-synthase (CBS) is linked to excess intracellular hydrogen sulfide (HS), a...
4.
Mouli K, Liopo A, McHugh E, Underwood E, Zhao J, Dash P, et al.
Adv Healthc Mater
. 2024 Sep;
:e2401629.
PMID: 39329414
Pro-energetic effects of functionalized, oxidized carbon nanozymes (OCNs) are reported. OCNs, derived from harsh acid oxidation of single-wall carbon nanotubes or activated charcoal are previously shown to possess multiple nanozymatic...
5.
Maloji Rao V, Vasquez V, Kodavati M, Mitra J, Provasek V, Voh A, et al.
Res Sq
. 2024 Aug;
PMID: 39108479
Intracerebral hemorrhage (ICH) poses acute fatality and long-term neurological risks due to hemin and iron accumulation from hemoglobin breakdown. Our observation that hemin induces DNA double-strand breaks (DSBs), prompting a...
6.
Derry P, Liopo A, Mouli K, McHugh E, Vo A, McKelvey A, et al.
Adv Mater
. 2023 Jun;
36(10):e2211241.
PMID: 37272655
Hydrogen sulfide (H S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H S is elevated and...
7.
McHugh E, Liopo A, Mendoza K, Robertson C, Wu G, Wang Z, et al.
Adv Mater
. 2023 Mar;
36(10):e2211239.
PMID: 36940058
Carbon-based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials as...
8.
Olson K, Clear K, Derry P, Gao Y, Ma Z, Cieplik N, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362080
1,4-Napththoquinones (NQs) are clinically relevant therapeutics that affect cell function through production of reactive oxygen species (ROS) and formation of adducts with regulatory protein thiols. Reactive sulfur species (RSS) are...
9.
Olson K, Derry P, Kent T, Straub K
Antioxid Redox Signal
. 2022 Jul;
38(1-3):68-94.
PMID: 35819295
Nutraceuticals are ingested for health benefits, in addition to their general nutritional value. These dietary supplements have become increasingly popular since the late 20th century and they are a rapidly...
10.
Olson K, Clear K, Derry P, Gao Y, Ma Z, Wu G, et al.
Free Radic Biol Med
. 2022 Feb;
182:119-131.
PMID: 35202787
In the canonical pathway for mitochondrial HS oxidation electrons are transferred from sulfide:quinone oxidoreductase (SQR) to complex III via ubiquinone (CoQ). We previously observed that a number of quinones directly...