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Paul H Schlesinger

Explore the profile of Paul H Schlesinger including associated specialties, affiliations and a list of published articles. Areas
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Articles 72
Citations 1804
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Recent Articles
1.
Tourkova I, Larrouture Q, Liu S, Luo J, Shipman K, Onwuka K, et al.
Bone Rep . 2024 Apr; 21:101763. PMID: 38666049
Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na/H exchange, but apical proton uptake is undefined. We found high expression of the...
2.
Tourkova I, Larrouture Q, Liu S, Luo J, Schlesinger P, Blair H
Am J Physiol Cell Physiol . 2024 Jan; 326(3):C843-C849. PMID: 38223929
The phosphodiesterase enzymes mediate calcium-phosphate deposition in various tissues, although which enzymes are active in bone mineralization is unclear. Using gene array analysis, we found that a member of ecto-nucleotide...
3.
Blair H, Larrouture Q, Tourkova I, Nelson D, Dobrowolski S, Schlesinger P
J Cell Biochem . 2023 Nov; 124(12):1889-1899. PMID: 37991446
We review unique properties of bone formation including current understanding of mechanisms of bone mineral transport. We focus on formation only; mechanism of bone degradation is a separate topic not...
4.
Tourkova I, Larrouture Q, Onwuka K, Liu S, Luo J, Schlesinger P, et al.
Am J Physiol Cell Physiol . 2023 Jul; 325(3):C613-C622. PMID: 37519232
We studied osteoblast bone mineral transport and matrix proteins as a function of age. In isolated bone marrow cells from long bones of young (3 or 4 mo) and old...
5.
Kumar H, Jimah J, Misal S, Salinas N, Fried M, Schlesinger P, et al.
J Biol Chem . 2022 Jul; 298(9):102241. PMID: 35809642
Malaria and other apicomplexan-caused diseases affect millions of humans, agricultural animals, and pets. Cell traversal is a common feature used by multiple apicomplexan parasites to migrate through host cells and...
6.
Larrouture Q, Tourkova I, Stolz D, Riazanski V, Onwuka K, Franks J, et al.
Biochem Biophys Res Commun . 2021 Oct; 580:14-19. PMID: 34607258
Osteoblasts in vivo form an epithelial-like layer with tight junctions between cells. Bone formation involves mineral transport into the matrix and acid transport to balance pH levels. To study the...
7.
Blair H, Schlesinger P
Elife . 2021 Jan; 10. PMID: 33480844
Osteocalcin is a bone matrix protein that acts like a hormone when it reaches the blood, and has different effects in mice and humans.
8.
Schlesinger P, Braddock D, Larrouture Q, Ray E, Riazanski V, Nelson D, et al.
Bone . 2020 Aug; 141:115621. PMID: 32858255
Three physiologically mineralizing tissues - teeth, cartilage and bone - have critical common elements and important evolutionary relationships. Phylogenetically the most ancient densely mineralized tissue is teeth. In jawless fishes...
9.
Schlesinger P, Blair H, Stolz D, Riazanski V, Ray E, Tourkova I, et al.
Am J Physiol Cell Physiol . 2019 Sep; 318(1):C111-C124. PMID: 31532718
Bone differs from other connective tissues; it is isolated by a layer of osteoblasts that are connected by tight and gap junctions. This allows bone to create dense lamellar type...
10.
Pan H, Palekar R, Hou K, Bacon J, Yan H, Springer L, et al.
Int J Nanomedicine . 2018 Sep; 13:5187-5205. PMID: 30233180
Background: A direct and independent role of inflammation in atherothrombosis was recently highlighted by the Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) trial, showing the benefit of inhibiting signaling molecules, eg,...