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Paul H Savelkoul

Explore the profile of Paul H Savelkoul including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 661
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Recent Articles
1.
Galazzo G, van Best N, Benedikter B, Janssen K, Bervoets L, Driessen C, et al.
Front Cell Infect Microbiol . 2020 Aug; 10:403. PMID: 32850498
Next-generation sequencing (NGS) has instigated the research on the role of the microbiome in health and disease. The compositional nature of such microbiome datasets makes it however challenging to identify...
2.
Hertz F, Budding A, van der Lugt-Degen M, Savelkoul P, Lobner-Olesen A, Frimodt-Moller N
Antibiotics (Basel) . 2020 Apr; 9(4). PMID: 32316518
Studies on human and mouse gastrointestinal microbiota have correlated the composition of the microbiota to a variety of diseases, as well as proved it vital to prevent colonization with resistant...
3.
Galazzo G, van Best N, Bervoets L, Dapaah I, Savelkoul P, Hornef M, et al.
Gastroenterology . 2020 Jan; 158(6):1584-1596. PMID: 31958431
Background & Aims: Establishment of the gastrointestinal microbiota during infancy affects immune system development and oral tolerance induction. Perturbations in the microbiome during this period can contribute to development of...
4.
Benedikter B, Bouwman F, Vajen T, Heinzmann A, Grauls G, Mariman E, et al.
Sci Rep . 2017 Nov; 7(1):15297. PMID: 29127410
Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We hypothesized that ultrafiltration followed by size exclusion...
5.
Van De Pol J, van Best N, Mbakwa C, Thijs C, Savelkoul P, Arts I, et al.
Front Microbiol . 2017 Mar; 8:355. PMID: 28344572
The gut microbiota represents a complex and diverse ecosystem with a profound impact on human health, promoting immune maturation, and host metabolism as well as colonization resistance. Important members that...
6.
Tedjo D, Smolinska A, Savelkoul P, Masclee A, van Schooten F, Pierik M, et al.
Sci Rep . 2016 Oct; 6:35216. PMID: 27734914
Monitoring mucosal inflammation is crucial to prevent complications and disease progression in Crohn's disease (CD). Endoscopy is the current standard, but is invasive. Clinical activity scores and non-invasive biochemical markers...
7.
Kluytmans-van den Bergh M, Huizinga P, Bonten M, Bos M, De Bruyne K, Friedrich A, et al.
Euro Surveill . 2016 Mar; 21(9):30149. PMID: 26967540
Recently, the plasmid-mediated colistin resistance gene mcr-1 was found in Enterobacteriaceae from humans, pigs and retail meat in China. Several reports have documented global presence of the gene in Enterobacteriaceae...
8.
Mbakwa C, Penders J, Savelkoul P, Thijs C, Dagnelie P, Mommers M, et al.
Obesity (Silver Spring) . 2015 Nov; 23(12):2508-16. PMID: 26524691
Objective: To prospectively investigate the presence and counts of archaea in feces of 472 children in association with weight development from 6 to 10 years of age. Methods: Within the...
9.
Tedjo D, Jonkers D, Savelkoul P, Masclee A, van Best N, Pierik M, et al.
PLoS One . 2015 May; 10(5):e0126685. PMID: 26024217
Large-scale cohort studies are currently being designed to investigate the human microbiome in health and disease. Adequate sampling strategies are required to limit bias due to shifts in microbial communities...
10.
Wills E, Jonkers D, Savelkoul P, Masclee A, Pierik M, Penders J
PLoS One . 2014 Mar; 9(3):e90981. PMID: 24608638
Background: Limited studies have examined the intestinal microbiota composition in relation to changes in disease course of IBD over time. We aimed to study prospectively the fecal microbiota in IBD...