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Paul F Morrison

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Articles 12
Citations 469
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Recent Articles
1.
Lonser R, Sarntinoranont M, Morrison P, Oldfield E
J Neurosurg . 2014 Nov; 122(3):697-706. PMID: 25397365
Convection-enhanced delivery (CED) is a bulk flow-driven process. Its properties permit direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while bypassing the blood-brain barrier. Development of surrogate imaging...
2.
Szerlip N, Walbridge S, Yang L, Morrison P, Degen J, Jarrell S, et al.
J Neurosurg . 2007 Sep; 107(3):560-7. PMID: 17886556
Object: Despite recent evidence showing that convection-enhanced delivery (CED) of viruses and virus-sized particles to the central nervous system (CNS) is possible, little is known about the factors influencing distribution...
3.
Morrison P, Lonser R, Oldfield E
J Neurosurg . 2007 Jul; 107(1):74-83. PMID: 17639877
Object: The authors conducted an analysis of the distribution of glial cell line-derived neurotrophic factor in the human striatum following convection-enhanced delivery. Methods: Computational examinations of the effects of differing...
4.
Murad G, Walbridge S, Morrison P, Szerlip N, Butman J, Oldfield E, et al.
J Neurosurg . 2007 Apr; 106(2):351-6. PMID: 17410722
Object: To determine if the potent antiglioma chemotherapeutic agent gemcitabine could be delivered to the brainstem safely at therapeutic doses while monitoring its distribution using a surrogate magnetic resonance (MR)...
5.
Murad G, Walbridge S, Morrison P, Garmestani K, Degen J, Brechbiel M, et al.
Clin Cancer Res . 2006 May; 12(10):3145-51. PMID: 16707614
Purpose: To determine if the tumor-targeted cytotoxin interleukin 13 bound to Pseudomonas exotoxin (IL13-PE) could be delivered to the brainstem safely at therapeutic doses while monitoring its distribution in real-time...
6.
Chen M, Hoffer A, Morrison P, Hamilton J, Hughes J, Schlageter K, et al.
J Neurosurg . 2005 Sep; 103(2):311-9. PMID: 16175862
Object: Achieving distribution of gene-carrying vectors is a major barrier to the clinical application of gene therapy. Because of the blood-brain barrier, the distribution of genetic vectors to the central...
7.
Croteau D, Walbridge S, Morrison P, Butman J, Vortmeyer A, Johnson D, et al.
J Neurosurg . 2005 Jan; 102(1):90-7. PMID: 15658101
Object: Convection-enhanced delivery (CED) is increasingly used to distribute therapeutic agents to locations in the central nervous system. The optimal application of convective distribution of various agents requires the development...
8.
Morrison P, Chattoraj D
Plasmid . 2004 Jun; 52(1):13-30. PMID: 15212889
For stability, the replication of unit-copy plasmids ought to occur by a highly controlled process. We have characterized the replication dynamics of a unit-copy plasmid F by a replication rate...
9.
Sarntinoranont M, Iadarola M, Lonser R, Morrison P
Am J Physiol Regul Integr Comp Physiol . 2003 Jun; 285(1):R243-54. PMID: 12793999
Convection-enhanced delivery of substance P (SP) nocitoxins to the spinal cord interstitium is under consideration for the treatment of chronic pain. To characterize treatment protocols, a three-dimensional finite-element model of...
10.
Sarntinoranont M, Banerjee R, Lonser R, Morrison P
Ann Biomed Eng . 2003 May; 31(4):448-61. PMID: 12723686
Convection-enhanced interstitial infusion can deliver macromolecular drugs to large tissue volumes of the central nervous system. To characterize infusion into the spinal cord, an image-based three-dimensional finite element model of...