Paul E Blower
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Explore the profile of Paul E Blower including associated specialties, affiliations and a list of published articles.
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10
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354
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Recent Articles
1.
Pham A, Blower P, Alvarado O, Ravula R, Gout P, Huang Y
J Pharmacol Exp Ther
. 2009 Dec;
332(3):949-58.
PMID: 20007406
The x(c)(-) cystine/glutamate antiporter has been implicated in GSH-based chemoresistance because it mediates cellular uptake of cystine/cysteine for sustenance of intracellular GSH levels. Celastrol, isolated from a Chinese medicinal herb,...
2.
Pham A, Wang J, Fang J, Gao X, Zhang Y, Blower P, et al.
Pharm Res
. 2008 Dec;
26(4):936-45.
PMID: 19067123
Purpose: Geldanamycin and its analogues belong to a new class of anticancer agents that inhibit the molecular chaperone heat shock protein 90. We hypothesized that membrane transporters expressed on tumor...
3.
Ikediobi O, Reimers M, Durinck S, Blower P, Futreal A, Stratton M, et al.
Mol Cancer Ther
. 2008 Jun;
7(6):1337-46.
PMID: 18524847
The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. We previously sequenced 24 cancer...
4.
Blower P, Chung J, Verducci J, Lin S, Park J, Dai Z, et al.
Mol Cancer Ther
. 2008 Jan;
7(1):1-9.
PMID: 18187804
MicroRNAs are strongly implicated in such processes as development, carcinogenesis, cell survival, and apoptosis. It is likely, therefore, that they can also modulate sensitivity and resistance to anticancer drugs in...
5.
Liu R, Blower P, Pham A, Fang J, Dai Z, Wise C, et al.
Mol Pharmacol
. 2007 Sep;
72(6):1637-46.
PMID: 17875604
The cystine-glutamate transporter SLC7A11 has been implicated in chemoresistance, by supplying cystine to the cell for glutathione maintenance. In the NCI-60 cell panel, SLC7A11 expression shows negative correlation with growth...
6.
Blower P, Verducci J, Lin S, Zhou J, Chung J, Dai Z, et al.
Mol Cancer Ther
. 2007 May;
6(5):1483-91.
PMID: 17483436
Advances in the understanding of cancer cell biology and response to drug treatment have benefited from new molecular technologies and methods for integrating information from multiple sources. The NCI-60, a...
7.
Huang Y, Blower P, Liu R, Dai Z, Pham A, Moon H, et al.
Pharm Res
. 2007 Apr;
24(9):1702-12.
PMID: 17457659
Purpose: A prerequisite for geldanamycin (GA, NSC122750) to targeting heat shock protein 90 and inhibiting tumor growth is sufficient intracellular drug accumulation. We hypothesized that membrane transporters on tumor cells...
8.
Blower P, Cross K, Eichler G, Myatt G, Weinstein J, Yang C
Comb Chem High Throughput Screen
. 2006 Feb;
9(2):115-22.
PMID: 16475969
Sequential screening is an iterative procedure that can greatly increase hit rates over random screening or non-iterative procedures. We studied the effects of three factors on enrichment rates: the method...
9.
Blower P, Cross K
Curr Top Med Chem
. 2006 Feb;
6(1):31-9.
PMID: 16454756
Decision trees are among the most popular of the new statistical learning methods being used in the pharmaceutical industry for predicting quantitative structure-activity relationships. This article reviews applications of decision...
10.
Yang C, Cross K, Myatt G, Blower P, Rathman J
J Med Chem
. 2004 Nov;
47(24):5984-94.
PMID: 15537353
A new approach to predicting the biological activity of small molecule pharmaceutics is demonstrated. Structural features of medicinal chemistry building blocks are used as 2-D molecular descriptors. These descriptors include...