Paul Driggers
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Explore the profile of Paul Driggers including associated specialties, affiliations and a list of published articles.
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11
Citations
111
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Recent Articles
1.
Schwartz A, Malik M, Driggers P, Catherino W
F S Sci
. 2024 Dec;
PMID: 39733929
Objective: To determine if the oral gonadotropin-releasing hormone antagonist relugolix affects leiomyoma extracellular matrix production through the transforming growth factor-beta (TGF-β) pathway. Design: Laboratory study. Subjects: None. Exposure: Exposure of...
2.
Echague C, Malik M, Driggers P, Catherino W
F S Sci
. 2024 Jul;
5(4):342-351.
PMID: 39004304
Objective: To evaluate the impact of coenzyme Q-10 (CoQ-10) on the dysregulated synthesis of extracellular matrix proteins mediated by transforming growth factor beta 3 (TGF-β3) in uterine leiomyomas. Design: Laboratory...
3.
Britten J, Roura-Monllor J, Malik M, Moran S, DeAngelis A, Driggers P, et al.
F S Sci
. 2023 Dec;
5(1):80-91.
PMID: 38043603
Objectives: To assess the effect of simvastatin on uterine leiomyoma growth and extracellular matrix (ECM) deposition. Design: Laboratory analysis of human leiomyoma cell culture, xenograft in a mouse model, and...
4.
Malik M, Britten J, DeAngelis A, Sitler C, Moran S, Roura-Monllor J, et al.
F S Sci
. 2022 Oct;
4(1):74-89.
PMID: 36273722
Objective: To determine whether a curcumin-supplemented diet would prevent and/or treat uterine leiomyoma growth in our mouse xenograft model. Design: Animal study. Setting: Laboratory study. Patient(s): N/A. Intervention(s): Curcumin-supplemented diet....
5.
Maher J, Islam M, Yin O, Brennan J, Gough E, Driggers P, et al.
F S Sci
. 2022 May;
3(2):118-129.
PMID: 35560009
Objective: To determine whether the mechanotransduction and pharmacomanipulation of A-kinase anchoring protein 13 (AKAP13) altered Hippo signaling pathway transcription and growth factors in granulosa cells. Primary ovarian insufficiency is the...
6.
DeAngelis A, Malik M, Britten J, Driggers P, Catherino W
F S Sci
. 2022 May;
2(4):396-406.
PMID: 35559862
Objective: To assess and characterize the role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in the development of uterine leiomyoma. Design: Laboratory study. Setting: Academic research center. Patient(s): Not...
7.
Bateman N, Tarney C, Abulez T, Soltis A, Zhou M, Conrads K, et al.
Sci Rep
. 2021 May;
11(1):9371.
PMID: 33931688
Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from...
8.
Garg D, Ng S, Maravet Baig K, Driggers P, Segars J
Trends Endocrinol Metab
. 2017 Jun;
28(9):656-668.
PMID: 28651856
Progesterone is essential for pregnancy maintenance and menstrual cycle regulation. Hormone action has been primarily ascribed to the well-characterized classical signaling pathway involving ligand binding, activation of nuclear progesterone receptors...
9.
Koide H, Holmbeck K, Lui J, Guo X, Driggers P, Chu T, et al.
J Bone Miner Res
. 2015 Apr;
30(10):1887-95.
PMID: 25892096
Mechanical stimulation is crucial to bone growth and triggers osteogenic differentiation through a process involving Rho and protein kinase A. We previously cloned a gene (AKAP13, aka BRX) encoding a...
10.
Catherino W, Malik M, Driggers P, Chappel S, Segars J, Davis J
J Steroid Biochem Mol Biol
. 2010 May;
122(4):279-86.
PMID: 20493256
Uterine leiomyomas are highly prevalent and often symptomatic, but current medical therapies are limited. A novel, potent, selective, orally active therapy is needed. The goal of these studies was to...