Paul Dp Pharoah
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Explore the profile of Paul Dp Pharoah including associated specialties, affiliations and a list of published articles.
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14
Citations
889
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Recent Articles
1.
Nelson B, Hamilton P, Phung M, Milne K, Harris B, Thornton S, et al.
J Clin Invest
. 2024 Oct;
134(24).
PMID: 39470729
BACKGROUNDDespite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment.METHODSWe evaluated the tumor microenvironment of this...
2.
Kentistou K, Kaisinger L, Stankovic S, Vaudel M, de Oliveira E, Messina A, et al.
medRxiv
. 2023 Jul;
PMID: 37503126
Pubertal timing varies considerably and has been associated with a range of health outcomes in later life. To elucidate the underlying biological mechanisms, we performed multi-ancestry genetic analyses in ~800,000...
3.
Kobel M, Kang E, Weir A, Rambau P, Lee C, Nelson G, et al.
J Pathol Clin Res
. 2023 Mar;
9(3):208-222.
PMID: 36948887
Our objective was to test whether p53 expression status is associated with survival for women diagnosed with the most common ovarian carcinoma histotypes (high-grade serous carcinoma [HGSC], endometrioid carcinoma [EC],...
4.
Heinze K, Nazeran T, Lee S, Kramer P, Cairns E, Chiu D, et al.
J Pathol
. 2021 Dec;
256(4):388-401.
PMID: 34897700
ARID1A (BAF250a) is a component of the SWI/SNF chromatin modifying complex, plays an important tumour suppressor role, and is considered prognostic in several malignancies. However, in ovarian carcinomas there are...
5.
Pavanello M, Chan I, Ariff A, Pharoah P, Gayther S, Ramus S
Cancers (Basel)
. 2020 Oct;
12(10).
PMID: 33086730
A family history of ovarian or breast cancer is the strongest risk factor for epithelial ovarian cancer (EOC). Germline deleterious variants in the and genes confer EOC risks by age...
6.
Goode E, Block M, Kalli K, Vierkant R, Chen W, Fogarty Z, et al.
JAMA Oncol
. 2017 Oct;
3(12):e173290.
PMID: 29049607
Importance: Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns of CD8+ TILs by histotype and in relation to...
7.
Decker B, Allen J, Luccarini C, Pooley K, Shah M, Bolla M, et al.
J Med Genet
. 2017 Aug;
54(11):732-741.
PMID: 28779002
Background: Breast cancer (BC) is the most common malignancy in women and has a major heritable component. The risks associated with most rare susceptibility variants are not well estimated. To...
8.
Southey M, Goldgar D, Winqvist R, Pylkas K, Couch F, Tischkowitz M, et al.
J Med Genet
. 2016 Sep;
53(12):800-811.
PMID: 27595995
Background: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of...
9.
Ong J, Cuellar-Partida G, Lu Y, Fasching P, Hein A, Burghaus S, et al.
Int J Epidemiol
. 2016 Sep;
45(5):1619-1630.
PMID: 27594614
Background: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with...
10.
Dixon S, Nagle C, Thrift A, Pharoah P, Pearce C, Zheng W, et al.
Int J Epidemiol
. 2016 Jul;
45(3):884-95.
PMID: 27401727
Background: Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds...