Paul D Pharoah
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Explore the profile of Paul D Pharoah including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Tyrer J, Peng P, DeVries A, Gayther S, Jones M, Pharoah P
BMC Genomics
. 2024 Sep;
25(1):878.
PMID: 39294559
Background: As precision medicine advances, polygenic scores (PGS) have become increasingly important for clinical risk assessment. Many methods have been developed to create polygenic models with increased accuracy for risk...
2.
Burn L, Burn L, Wetscherek M, Ta Wetscherek M, Pharoah P, Pharoah P, et al.
QJM
. 2024 Jul;
117(12):837-845.
PMID: 38976637
Introduction: Spontaneous pneumothorax recurs in 30-54% of patients without surgery. Identifying individuals likely to suffer a recurrence, who might benefit from pre-emptive surgery, is challenging. Previous meta-analysis suggested a relationship...
3.
Chowdhury A, Pharoah P, Rueda O
Breast Cancer Res
. 2023 Feb;
25(1):17.
PMID: 36755280
Background: Breast cancer is one of the three most common cancers worldwide and is the most common malignancy in women. Treatment approaches for breast cancer are diverse and varied. Clinicians...
4.
Nakamura K, Reid B, Chen A, Chen Z, Goode E, Permuth J, et al.
Am J Hum Genet
. 2021 Dec;
109(1):116-135.
PMID: 34965383
The high-grade serous ovarian cancer (HGSOC) risk locus at chromosome 1p34.3 resides within a frequently amplified genomic region signifying the presence of an oncogene. Here, we integrate in silico variant-to-function...
5.
Sammut S, Crispin-Ortuzar M, Chin S, Provenzano E, Bardwell H, Ma W, et al.
Nature
. 2021 Dec;
601(7894):623-629.
PMID: 34875674
Breast cancers are complex ecosystems of malignant cells and the tumour microenvironment. The composition of these tumour ecosystems and interactions within them contribute to responses to cytotoxic therapy. Efforts to...
6.
Matsumoto K, Lim D, Pharoah P, Maher E, Marciniak S
Eur J Hum Genet
. 2021 Jul;
29(11):1595-1600.
PMID: 34267338
Individuals with Birt-Hogg-Dubé syndrome (BHDS) may develop fibrofolliculomas, pneumothorax and/or renal cell carcinoma (RCC). Currently, all patients with pathogenic FLCN variants are recommended to have renal surveillance. It has however...
7.
Zhang P, Kitchen-Smith I, Xiong L, Stracquadanio G, Brown K, Richter P, et al.
Cancer Res
. 2021 Feb;
81(7):1667-1680.
PMID: 33558336
Insights into oncogenesis derived from cancer susceptibility loci (SNP) hold the potential to facilitate better cancer management and treatment through precision oncology. However, therapeutic insights have thus far been limited...
8.
Dong J, Maj C, Tsavachidis S, Ostrom Q, Gharahkhani P, Anderson L, et al.
Gastroenterology
. 2020 Sep;
159(6):2065-2076.e1.
PMID: 32918910
Background & Aims: Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence...
9.
Sheikh M, Poustchi H, Pourshams A, Khoshnia M, Gharavi A, Zahedi M, et al.
Environ Health Perspect
. 2020 Jul;
128(6):67002.
PMID: 32609005
Background: Three billion people burn nonclean fuels for household purposes. Limited evidence suggests a link between household fuel use and gastrointestinal (GI) cancers. Objectives: We investigated the relationship between indoor...
10.
Sheikh M, Shakeri R, Poustchi H, Pourshams A, Etemadi A, Islami F, et al.
Lancet Glob Health
. 2020 May;
8(5):e649-e660.
PMID: 32353313
Background: Evidence is emerging for a role of opiates in various cancers. In this study, we aimed to investigate the association between regular opium use and cancer incidence. Methods: This...