Paul A White
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Explore the profile of Paul A White including associated specialties, affiliations and a list of published articles.
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123
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1740
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Recent Articles
11.
Holzl-Armstrong L, Naevisdal A, Cox J, Long A, Chepelev N, Phillips D, et al.
Mutagenesis
. 2021 Jan;
35(6):453-463.
PMID: 33399867
Chemicals in commerce or under development must be assessed for genotoxicity; assessment is generally conducted using validated assays (e.g. Tk mouse lymphoma assay) as part of a regulatory process. Currently,...
12.
Keir J, Cakmak S, Blais J, White P
J Expo Sci Environ Epidemiol
. 2020 Feb;
31(2):386-397.
PMID: 32066882
Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds formed during the incomplete combustion of organic matter. Several are mutagenic carcinogens; the magnitude of exposure can be assessed by examining...
13.
White P, Long A, Johnson G
Environ Mol Mutagen
. 2019 Dec;
61(1):66-83.
PMID: 31794061
The screen-and-bin approach for interpretation of genotoxicity data is predicated on three false assumptions: that genotoxicants are rare, that genotoxicity dose-response functions do not contain a low-dose region mechanistically characterized...
14.
Luijten M, Ball N, Dearfield K, Gollapudi B, Johnson G, Madia F, et al.
Environ Mol Mutagen
. 2019 Nov;
61(1):94-113.
PMID: 31709603
We recently published a next generation framework for assessing the risk of genomic damage via exposure to chemical substances. The framework entails a systematic approach with the aim to quantify...
15.
Gollapudi B, White P, Honma M
Mutat Res Genet Toxicol Environ Mutagen
. 2019 Nov;
848:403061.
PMID: 31708076
Assays for gene mutations in cultured mammalian cells, i.e., Mammalian Cell Gene Mutation (MCGM) assays, are widely used in genetic toxicology laboratories worldwide; over the past four decades they have...
16.
White P, Luijten M, Mishima M, Cox J, Hanna J, Maertens R, et al.
Mutat Res Genet Toxicol Environ Mutagen
. 2019 Nov;
847:403039.
PMID: 31699347
Chemical safety evaluations require assessment of genetic toxicity. Transgenic rodent (TGR) assays permit enumeration of mutations in chromosomally-integrated targets contained in shuttle vectors. In order to improve in vitro mutagenicity...
17.
Heflich R, Johnson G, Zeller A, Marchetti F, Douglas G, Witt K, et al.
Environ Mol Mutagen
. 2019 Oct;
61(1):34-41.
PMID: 31600846
Mutations induced in somatic cells and germ cells are responsible for a variety of human diseases, and mutation per se has been considered an adverse health concern since the early...
18.
Keir J, Akhtar U, Matschke D, White P, Kirkham T, Chan H, et al.
Sci Total Environ
. 2019 Sep;
698:134211.
PMID: 31514022
This study examined occupational exposures of Ottawa firefighters to combustion by-products and selected metals. We measured exposures to polycyclic aromatic hydrocarbons (PAHs), antimony, cadmium, and lead using (1) personal air...
19.
Samet J, Chiu W, Cogliano V, Jinot J, Kriebel D, Lunn R, et al.
J Natl Cancer Inst
. 2019 Sep;
112(1):30-37.
PMID: 31498409
The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to...
20.
Tran Y, Buick J, Keir J, Williams A, Swartz C, Recio L, et al.
Regul Toxicol Pharmacol
. 2019 Jul;
107:104427.
PMID: 31336127
The Canadian Domestic Substances List (DSL) contains chemicals that have not been tested for genotoxicity as their use pre-dates regulatory requirements. In the present study, (quantitative) structure-activity relationships ((Q)SAR) model...