Paul A Hamel
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Explore the profile of Paul A Hamel including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
334
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Recent Articles
11.
Chang H, Li Q, Moraes R, Lewis M, Hamel P
Int J Biochem Cell Biol
. 2010 May;
42(9):1462-71.
PMID: 20451654
Hedgehog (Hh) signalling is mediated through the Patched-1 (Ptch1) receptor. Hh-binding to Ptch1 blocks the inhibitory effects of Ptch1 on the activity of the transmembrane protein, Smoothened (Smo), resulting induction...
12.
Christova T, Mojtahedi G, Hamel P
Int J Biochem Cell Biol
. 2009 Dec;
42(5):630-40.
PMID: 20006729
The transcription factor, Pax3, alters transcription by binding directly to promoter regions harbouring sequences recognized by either its paired domain or its homeodomain. We demonstrated previously that the promoter regions...
13.
Moraes R, Chang H, Harrington N, Landua J, Prigge J, Lane T, et al.
Development
. 2009 Mar;
136(9):1423-32.
PMID: 19297414
Systemic hormones and local growth factor-mediated tissue interactions are essential for mammary gland development. Using phenotypic and transplantation analyses of mice carrying the mesenchymal dysplasia (mes) allele of patched 1...
14.
Joshi P, Chang H, Hamel P
Dev Biol
. 2006 Aug;
297(1):284-94.
PMID: 16916507
Postnatal development of the mammary gland is determined by reciprocal interactions between the ductal epithelia and adjacent stroma. Alx4 is a mesenchymally restricted homeodomain transcription factor expressed in a number...
15.
Boras-Granic K, Grosschedl R, Hamel P
Int J Dev Biol
. 2006 Aug;
50(7):601-10.
PMID: 16892173
Lymphoid Enhancer Factor-1 (Lef1) facilitates the assembly of transcriptional regulatory complexes and mediates nuclear responses to Wnt signals. We determined previously that the mesenchymally restricted, paired-like homeodomain protein Aristaless-like 4...
16.
Boras-Granic K, Chang H, Grosschedl R, Hamel P
Dev Biol
. 2006 May;
295(1):219-31.
PMID: 16678815
Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appendages such as hair follicles and mammary glands. Lef1-mediated canonical Wnt signaling is required for morphogenesis of these...
17.
Begum S, Emami N, Emani N, Cheung A, Wilkins O, Der S, et al.
Oncogene
. 2005 Feb;
24(11):1860-72.
PMID: 15688035
The oncogenic fusion protein, Pax3/FKHR, is a more potent transcription factor relative to its normal counterpart, Pax3. Since Pax3 induced a mesenchymal to epithelial transition (MET) in human SaOS-2 osteosarcomas,...
18.
Zakrison T, Hamel P, Hwang S
J Urban Health
. 2004 Oct;
81(4):596-605.
PMID: 15466841
Although the health impact of patients' trust in physicians has been well documented, less is known about the possible health effects of trust in police or paramedics. Homeless people frequently...
19.
Zakrison T, Shahen A, Mortaja S, Hamel P
Can J Psychiatry
. 2004 Feb;
49(1):60-3.
PMID: 14763680
Objective: To determine the prevalence of psychological morbidity among Palestinian children living in the southern Bethlehem District of the West Bank during July 2000. Methods: We undertook a descriptive study...
20.
Michno K, Boras-Granic K, Mill P, Hui C, Hamel P
Dev Biol
. 2003 Nov;
264(1):153-65.
PMID: 14623238
The embryonic mammary gland and hair follicle are both derived from the ventral ectoderm, and their development depends on a number of common fundamental developmental pathways. While the Hedgehog (Hh)...