Patrick R Fitzgerald
Overview
Explore the profile of Patrick R Fitzgerald including associated specialties, affiliations and a list of published articles.
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4
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54
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Recent Articles
1.
Fitzgerald P, Dixit A, Zhang C, Mobley D, Paegel B
J Chem Inf Model
. 2024 Jun;
64(12):4661-4672.
PMID: 38860710
DNA-encoded library technology grants access to nearly infinite opportunities to explore the chemical structure space for drug discovery. Successful navigation depends on the design and synthesis of libraries with appropriate...
2.
Fitzgerald P, Cochrane W, Paegel B
ACS Med Chem Lett
. 2023 Sep;
14(9):1295-1303.
PMID: 37736190
Dose-response, or "conforming" behavior, increases confidence in a screening hit's authenticity. Here, we demonstrate dose-response solid-phase DNA-encoded library (DEL) screening. Compound dose in microfluidic droplets is modulated via the UV...
3.
Cochrane W, Fitzgerald P, Paegel B
ACS Chem Biol
. 2021 Nov;
16(12):2752-2756.
PMID: 34806373
The global rise of multidrug resistant infections poses an imminent, existential threat. Numerous pipelines have failed to convert biochemically active molecules into bona fide antibacterials, owing to a lack of...
4.
Fitzgerald P, Paegel B
Chem Rev
. 2020 Oct;
121(12):7155-7177.
PMID: 33044817
Click chemistry, proposed nearly 20 years ago, promised access to novel chemical space by empowering combinatorial library synthesis with a "few good reactions". These click reactions fulfilled key criteria (broad...