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Patrick OKane

Explore the profile of Patrick OKane including associated specialties, affiliations and a list of published articles. Areas
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Articles 25
Citations 360
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Recent Articles
1.
Cahoon E, Grimm E, Mabuchi K, Mai J, Zhang R, Drozdovitch V, et al.
Thyroid . 2024 May; 34(7):890-898. PMID: 38757581
Although childhood exposure to radioactive iodine-131 (I-131) is an established risk factor for thyroid cancer, evidence for an association with thyroid nodules is less clear. The objective of this study...
2.
Savsani E, Shaw C, Forsberg F, Wessner C, Lyshchik A, OKane P, et al.
Radiology . 2023 Oct; 309(1):e230727. PMID: 37847138
Background Contrast-enhanced (CE) US has been studied for use in the detection of residual viable hepatocellular carcinoma (HCC) after locoregional therapy, but multicenter data are lacking. Purpose To compare two-dimensional...
3.
Lacerda Q, Falatah H, Liu J, Wessner C, Oeffinger B, Rochani A, et al.
Pharmaceutics . 2023 Apr; 15(4). PMID: 37111787
Tumor hypoxia (oxygen deficiency) is a major contributor to radiotherapy resistance. Ultrasound-sensitive microbubbles containing oxygen have been explored as a mechanism for overcoming tumor hypoxia locally prior to radiotherapy. Previously,...
4.
Lacerda Q, Rochani A, Oeffinger B, Liu J, Wessner C, Tahmasebi A, et al.
Int J Pharm . 2022 Aug; 625:122072. PMID: 35932933
Prior work has shown that microbubble-assisted delivery of oxygen improves tumor oxygenation and radiosensitivity, albeit over a limited duration. Lonidamine (LND) has been investigated because of its ability to stimulate...
5.
Chirikova E, McConnell R, OKane P, Yauseyenka V, Little M, Minenko V, et al.
Environ Health . 2022 Jan; 21(1):5. PMID: 34996456
Background: While there is a robust literature on environmental exposure to iodine-131 (I) in childhood and adolescence and the risk of thyroid cancer and benign nodules, little is known about...
6.
Delaney L, Tantawi M, Wessner C, Machado P, Forsberg F, Lyshchik A, et al.
Ultrasound Med Biol . 2021 Jun; 47(9):2523-2531. PMID: 34130880
Conventional cross-sectional imaging done shortly after radioembolization of hepatocellular carcinoma (HCC) does not reliably predict long-term response to treatment. This study evaluated whether quantitative contrast-enhanced ultrasound (CEUS) can predict the...
7.
Gummadi S, Koenig G, Wessner C, Machado P, Stem J, Forsberg F, et al.
J Ultrasound Med . 2021 Jun; 41(4):835-843. PMID: 34101877
Background: Small intestinal ischemia is a challenging diagnosis to make, even with the combination of imaging, laboratory analysis, and physical exam. This pilot study investigated the role of CEUS in...
8.
Eisenbrey J, Forsberg F, Wessner C, Delaney L, Bradigan K, Gummadi S, et al.
Radiology . 2020 Dec; 298(2):450-457. PMID: 33320067
Background US contrast agents are gas-filled microbubbles (MBs) that can be locally destroyed by using external US. Among other bioeffects, US-triggered MB destruction, also known as UTMD, has been shown...
9.
Delaney L, Ciraku L, Oeffinger B, Wessner C, Liu J, Li J, et al.
J Ultrasound Med . 2019 May; 38(12):3221-3228. PMID: 31124171
Objectives: Hypoxic cancer cells have been shown to be more resistant to radiation therapy than normoxic cells. Hence, this study investigated whether ultrasound (US)-induced rupture of oxygen-carrying microbubbles (MBs) would...
10.
Eisenbrey J, Shraim R, Liu J, Li J, Stanczak M, Oeffinger B, et al.
Int J Radiat Oncol Biol Phys . 2018 Feb; 101(1):88-96. PMID: 29477294
Purpose: Much of the volume of solid tumors typically exists in a chronically hypoxic microenvironment that has been shown to result in both chemotherapy and radiation therapy resistance. The purpose...