Patrick M McTamney
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Explore the profile of Patrick M McTamney including associated specialties, affiliations and a list of published articles.
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21
Citations
1953
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Recent Articles
1.
Sankhala R, Dussupt V, Chen W, Bai H, Martinez E, Jensen J, et al.
Structure
. 2023 Dec;
32(2):131-147.e7.
PMID: 38157856
Given the continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VoCs), immunotherapeutics that target conserved epitopes on the spike (S) glycoprotein have therapeutic advantages. Here,...
2.
Peretti A, Scorpio D, Kong W, Pang Y, McCarthy M, Ren K, et al.
Vaccine
. 2023 Feb;
41(10):1735-1742.
PMID: 36764908
In 2019, there were about 100,000 kidney transplants globally, with more than a quarter of them performed in the United States. Unfortunately, some engrafted organs are lost to polyomavirus-associated nephropathy...
3.
Brady T, Zhang T, Tuffy K, Haskins N, Du Q, Lin J, et al.
Microbiol Spectr
. 2022 Aug;
10(5):e0103422.
PMID: 35993765
AZD7442, a combination of two long-acting monoclonal antibodies (tixagevimab [AZD8895] and cilgavimab [AZD1061]), has been authorized for the prevention and treatment of coronavirus disease 2019 (COVID-19). The rapid emergence of...
4.
Loo Y, McTamney P, Arends R, Abram M, Aksyuk A, Diallo S, et al.
Sci Transl Med
. 2022 Jan;
14(635):eabl8124.
PMID: 35076282
Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, there remains a need for more prevention and treatment options for individuals remaining at risk of coronavirus disease...
5.
Joyce M, Chen W, Sankhala R, Hajduczki A, Thomas P, Choe M, et al.
Cell Rep
. 2021 Dec;
37(12):110143.
PMID: 34919799
The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-generation vaccines has been highlighted by the rise of variants of concern (VoCs) and the long-term threat of emerging coronaviruses....
6.
Dong J, Zost S, Greaney A, Starr T, Dingens A, Chen E, et al.
Nat Microbiol
. 2021 Sep;
6(10):1233-1244.
PMID: 34548634
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclonal antibodies-AZD8895 and...
7.
Joyce M, Chen W, Sankhala R, Hajduczki A, Thomas P, Choe M, et al.
bioRxiv
. 2021 May;
PMID: 34013273
Highlights: Iterative structure-based design of four Spike-domain Ferritin nanoparticle classes of immunogensSpFN-ALFQ and RFN-ALFQ immunization elicits potent neutralizing activity against SARS-CoV-2, variants of concern, and SARS-CoV-1Passively transferred IgG from immunized...
8.
Sangesland M, Ronsard L, Kazer S, Bals J, Boyoglu-Barnum S, Yousif A, et al.
Immunity
. 2019 Sep;
51(4):735-749.e8.
PMID: 31563464
Antibody paratopes are formed by hypervariable complementarity-determining regions (CDRH3s) and variable gene-encoded CDRs. The latter show biased usage in human broadly neutralizing antibodies (bnAbs) against both HIV and influenza virus,...
9.
Yassine H, McTamney P, Boyington J, Ruckwardt T, Crank M, Smatti M, et al.
Sci Rep
. 2018 Jun;
8(1):8628.
PMID: 29872070
A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, we utilized...
10.
Villar R, Patel J, Weaver G, Kanekiyo M, Wheatley A, Yassine H, et al.
Sci Rep
. 2016 Nov;
6:36298.
PMID: 27796362
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid...