Patrick Kim Chiaw
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Explore the profile of Patrick Kim Chiaw including associated specialties, affiliations and a list of published articles.
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11
Citations
206
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Recent Articles
1.
Kim Chiaw P, Hantouche C, Wong M, Matthes E, Robert R, Hanrahan J, et al.
PLoS One
. 2019 Aug;
14(8):e0220984.
PMID: 31408507
Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their...
2.
Alkhouri B, Denning R, Kim Chiaw P, Eckford P, Yu W, Li C, et al.
J Med Chem
. 2011 Nov;
54(24):8693-701.
PMID: 22074181
Cystic fibrosis is a genetic disease caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. In vitro experiments have demonstrated that 4-methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol (VRT-532, 1)...
3.
Kim Chiaw P, Eckford P, Bear C
Essays Biochem
. 2011 Oct;
50(1):233-48.
PMID: 21967060
Mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) cause CF (cystic fibrosis), a fatal genetic disease commonly leading to airway obstruction with recurrent airway inflammation and infection. Pulmonary obstruction...
4.
Yu W, Kim Chiaw P, Bear C
J Biol Chem
. 2011 May;
286(28):24714-25.
PMID: 21602569
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that cause loss of function of the CFTR channel on the apical surface of...
5.
Lamhonwah A, Bear C, Huan L, Kim Chiaw P, Ackerley C, Tein I
Ann Neurol
. 2010 Jun;
67(6):802-8.
PMID: 20517942
Objective: Individuals with cystic fibrosis (CF) have exercise intolerance and skeletal muscle weakness not solely attributable to physical inactivity or pulmonary function abnormalities. CF transmembrane conductance regulator (CFTR) has been...
6.
Kim Chiaw P, Wellhauser L, Huan L, Ramjeesingh M, Bear C
Mol Pharmacol
. 2010 May;
78(3):411-8.
PMID: 20501743
The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and...
7.
Kim Chiaw P, Huan L, Gagnon S, Ly D, Sweezey N, Rotin D, et al.
Chem Biol
. 2009 May;
16(5):520-30.
PMID: 19477416
The cystic fibrosis (CF)-causing mutant, deltaF508-CFTR, is misfolded and fails to traffic out of the endoplasmic reticulum (ER) to the cell surface. Introduction of second site mutations that disrupt a...
8.
Wellhauser L, Kim Chiaw P, Pasyk S, Li C, Ramjeesingh M, Bear C
Mol Pharmacol
. 2009 Apr;
75(6):1430-8.
PMID: 19339490
The deletion of Phe-508 (DeltaPhe508) constitutes the most prevalent of a number of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that cause cystic fibrosis (CF). This mutation leads...
9.
Cheung J, Kim Chiaw P, Deber C, Bear C
J Control Release
. 2009 Mar;
137(1):2-7.
PMID: 19285529
The intracellular delivery of a diverse array of cargos can be mediated by conjugation to cell-penetrating peptides (CPPs). To date, delivery of cargos into the cytosol via CPPs has been...
10.
Cheung J, Kim Chiaw P, Pasyk S, Bear C
Arch Biochem Biophys
. 2008 Apr;
476(1):95-100.
PMID: 18417076
CFTR is a member of the ABC (ATP binding cassette) superfamily of transporters. It is a multidomain membrane protein, which utilizes ATP to regulate the flux of its substrate through...