Patrick J Marsac
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Explore the profile of Patrick J Marsac including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
381
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Recent Articles
1.
Poozesh S, Algasem F, Azad M, Marsac P
Pharm Res
. 2022 Apr;
39(9):2033-2047.
PMID: 35386014
The aim of this work is to present a modeling tool to describe drying kinetics and delineate evolving physical and chemical behavior of multicomponent droplets during drying. Conservation equations coupled...
2.
Lu X, Li M, Arce F, Ling J, Setiawan N, Wang Y, et al.
Mol Pharm
. 2021 Nov;
18(12):4310-4321.
PMID: 34761934
The introduction of solubilizing additives has historically been an attractive approach to address the ever-growing proportion of poorly water-soluble drug (PWSD) compounds within the modern drug discovery pipeline. Lipid-formulations, and...
3.
Arce F, Setiawan N, Campbell H, Lu X, Nethercott M, Bummer P, et al.
Mol Pharm
. 2020 Sep;
17(11):4125-4140.
PMID: 32965123
Enabling formulations are an attractive approach to increase the dissolution rate, solubility, and oral bioavailability of poorly soluble compounds. With the growing prevalence of poorly soluble drug compounds in the...
4.
Defrese M, Farmer M, Long Y, Timmerman L, Bae Y, Marsac P
Mol Pharm
. 2020 Sep;
17(12):4548-4563.
PMID: 32965120
It is well established that polymers adopt a range of conformations and solution-state organization in response to varying solution environments, although very little work has been done to understand how...
5.
Mugheirbi N, Marsac P, Taylor L
Mol Pharm
. 2017 Oct;
14(12):4387-4402.
PMID: 29053281
For amorphous solid dispersions, understanding the phase behavior of a given drug-polymer blend and factors that influence miscibility is crucial to designing an optimally performing formulation. However, it can be...
6.
Correa-Soto C, Trasi N, Schmitt P, Su Y, Liu Z, Miller E, et al.
J Pharm Biomed Anal
. 2017 Sep;
146:86-95.
PMID: 28866472
Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD). However, most of these techniques do not enable the detection of very low levels of crystallinity (<1%)....
7.
Nie H, Xu W, Taylor L, Marsac P, Byrn S
Int J Pharm
. 2016 Dec;
517(1-2):203-215.
PMID: 27979765
Salt disproportionation (a conversion from the ionized to the neutral state) in solid formulations is a potential concern during manufacturing or storage of products containing a salt of the active...
8.
Nie H, Su Y, Zhang M, Song Y, Leone A, Taylor L, et al.
Mol Pharm
. 2016 Sep;
13(11):3964-3975.
PMID: 27653759
It has been technically challenging to specify the detailed molecular interactions and binding motif between drugs and polymeric inhibitors in the solid state. To further investigate drug-polymer interactions from a...
9.
Nie H, Xu W, Ren J, Taylor L, Marsac P, John C, et al.
Mol Pharm
. 2016 Aug;
13(10):3541-3552.
PMID: 27542728
Excipient-induced salt disproportionation (conversion from salt form to free form) in the solid state during storage or manufacturing is a severe formulation issue that can negatively influence product performance. However,...
10.
Nie H, Liu Z, Marks B, Taylor L, Byrn S, Marsac P
J Pharm Biomed Anal
. 2015 Nov;
118:328-337.
PMID: 26590700
It has always been challenging to use spectroscopic methods to analyze salt disproportionation in a multi-component tablet matrix due to the spectral interference generated by the various excipients. Although combining...