Patrick J Heizer
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Explore the profile of Patrick J Heizer including associated specialties, affiliations and a list of published articles.
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14
Citations
154
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Recent Articles
1.
McMurphy T, Park A, Heizer P, Bottenfield C, Kurasawa J, Ikeda Y, et al.
Sci Rep
. 2024 Nov;
14(1):28853.
PMID: 39572604
Adeno-associated virus (AAV) vectors can mediate long-term expression of immunogenic transgenes in vivo through transduction of tolerogenic cells in the liver. Tissue-targeted AAV vectors allow transduction of non-hepatic cells, but...
2.
Kim P, Kim J, Heizer P, Jung H, Tu Y, Presnell A, et al.
bioRxiv
. 2024 Nov;
PMID: 39554077
Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disorder characterized by multiple aging-like phenotypes, including disease in large arteries. HGPS is caused by an internally truncated prelamin A (progerin) that cannot...
3.
Kim P, Chen N, Heizer P, Tu Y, Weston T, Fong J, et al.
JCI Insight
. 2021 Aug;
6(16).
PMID: 34423791
The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that...
4.
Chen N, Kim P, Tu Y, Yang Y, Heizer P, Young S, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(25).
PMID: 34161290
Defects or deficiencies in nuclear lamins cause pathology in many cell types, and recent studies have implicated nuclear membrane (NM) ruptures as a cause of cell toxicity. We previously observed...
5.
Heizer P, Yang Y, Tu Y, Kim P, Chen N, Hu Y, et al.
J Lipid Res
. 2020 Jan;
61(3):413-421.
PMID: 31941672
Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl-prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl-prelamin A...
6.
Hu X, Weston T, He C, Jung R, Heizer P, Young B, et al.
Elife
. 2019 Sep;
8.
PMID: 31486771
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind...
7.
Hu X, Matsumoto K, Jung R, Weston T, Heizer P, He C, et al.
Elife
. 2019 Jun;
8.
PMID: 31169500
GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination...
8.
Beigneux A, Allan C, Sandoval N, Cho G, Heizer P, Jung R, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(13):6319-6328.
PMID: 30850549
Lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma lipoproteins, is assumed to be active only as a homodimer. In support of this idea, several groups have reported that...
9.
Allan C, Heizer P, Tu Y, Sandoval N, Jung R, Morales J, et al.
J Lipid Res
. 2019 Jan;
60(4):869-879.
PMID: 30598475
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), the protein that shuttles LPL to the capillary lumen, is essential for plasma triglyceride metabolism. When GPIHBP1 is absent, LPL remains stranded within...
10.
Larsson M, Allan C, Heizer P, Tu Y, Sandoval N, Jung R, et al.
J Lipid Res
. 2018 Feb;
59(4):706-713.
PMID: 29449313
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In mice, LPL remains stranded in...