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Patrick Heizer

Explore the profile of Patrick Heizer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 197
Followers 0
Related Specialties
Science
General Medicine
Biochemistry
Top 10 Co-Authors
Stephen G Young
Loren G Fong
Thomas A Weston
Haibo Jiang
Cuiwen He
Peter Tontonoz
Yiping Tu
Xuchen Hu
Rachel S Jung
Ye Yang
Published In
Proc Natl Acad Sci U S A
Cell Metab
Sci Transl Med
Biochem Biophys Res Commun
Affiliations
Soon will be listed here.
Recent Articles
1.
Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures
Song W, Yang Y, Heizer P, Tu Y, Weston T, Kim J, et al.
Proc Natl Acad Sci U S A . 2023 Feb; 120(8):e2219833120. PMID: 36787365
Lipoprotein lipase (LPL) is secreted into the interstitial spaces by parenchymal cells and then transported into capillaries by GPIHBP1. LPL carries out the lipolytic processing of triglyceride (TG)-rich lipoproteins (TRLs),...
2.
Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins
He C, Jiang H, Song W, Riezman H, Tontonoz P, Weston T, et al.
Proc Natl Acad Sci U S A . 2020 May; 117(19):10476-10483. PMID: 32354992
Cholesterol-laden macrophage foam cells are a hallmark of atherosclerosis. For that reason, cholesterol metabolism in macrophages has attracted considerable scrutiny, particularly the mechanisms by which macrophages unload surplus cholesterol (a...
3.
An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death
Chen N, Yang Y, Weston T, Belling J, Heizer P, Tu Y, et al.
Proc Natl Acad Sci U S A . 2019 Dec; 116(51):25870-25879. PMID: 31796586
Deficiencies in either lamin B1 or lamin B2 cause both defective migration of cortical neurons in the developing brain and reduced neuronal survival. The neuronal migration abnormality is explained by...
4.
Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome
Kim P, Luu J, Heizer P, Tu Y, Weston T, Chen N, et al.
Sci Transl Med . 2018 Sep; 10(460). PMID: 30257952
Hutchinson-Gilford progeria syndrome is a disorder of premature aging in children caused by de novo mutations in that lead to the synthesis of an internally truncated form of prelamin A...
5.
NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes
He C, Hu X, Weston T, Jung R, Heizer P, Tu Y, et al.
Biochem Biophys Res Commun . 2018 Sep; 504(4):899-902. PMID: 30224066
Heterogeneity in the metabolic properties of adipocytes in white adipose tissue has been well documented. We sought to investigate metabolic heterogeneity in adipocytes of brown adipose tissue (BAT), focusing on...
6.
Macrophages release plasma membrane-derived particles rich in accessible cholesterol
He C, Hu X, Weston T, Jung R, Sandhu J, Huang S, et al.
Proc Natl Acad Sci U S A . 2018 Aug; 115(36):E8499-E8508. PMID: 30127022
Macrophages are generally assumed to unload surplus cholesterol through direct interactions between ABC transporters on the plasma membrane and HDLs, but they have also been reported to release cholesterol-containing particles....
7.
NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes
He C, Weston T, Jung R, Heizer P, Larsson M, Hu X, et al.
Cell Metab . 2018 May; 27(5):1055-1066.e3. PMID: 29719224
The processing of triglyceride-rich lipoproteins (TRLs) in capillaries provides lipids for vital tissues, but our understanding of TRL metabolism is limited, in part because TRL processing and lipid movement have...