Patrick H Roseboom
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Explore the profile of Patrick H Roseboom including associated specialties, affiliations and a list of published articles.
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423
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Recent Articles
1.
Bronk G, Lardenoije R, Koolman L, Klengel C, Dan S, Howell B, et al.
bioRxiv
. 2024 Oct;
PMID: 39416061
Because DNA methylation changes reliably with age, machine learning models called epigenetic clocks can estimate an individual's age based on their DNA methylation profile. This epigenetic measure of age can...
2.
Aggarwal N, Tromp D, Blackford J, Pine D, Roseboom P, Williams L, et al.
Am J Psychiatry
. 2024 Mar;
181(4):299-309.
PMID: 38476042
Objective: Anxiety disorders are among the most common psychiatric disorders in youths and emerge during childhood. This is also a period of rapid white matter (WM) development, which is critical...
3.
Tromp D, Fox A, Riedel M, Oler J, Zhou X, Roseboom P, et al.
Psychoneuroendocrinology
. 2024 Jan;
162:106953.
PMID: 38232531
Background: Evidence suggests that early life adversity is associated with maladaptive behaviors and is commonly an antecedent of stress-related psychopathology. This is particularly relevant to rearing in primate species as...
4.
Mueller S, Oler J, Roseboom P, Aggarwal N, Kenwood M, Riedel M, et al.
Curr Res Neurobiol
. 2023 Nov;
5:100111.
PMID: 38020807
Anxiety disorders are among the most prevalent psychiatric disorders, with symptoms often beginning early in life. To model the pathophysiology of human pathological anxiety, we utilized Designer Receptors Exclusively Activated...
5.
Kenwood M, Souaiaia T, Kovner R, Fox A, French D, Oler J, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(49):e2305775120.
PMID: 38011550
Anxiety disorders are among the most prevalent psychiatric disorders, causing significant suffering and disability. Relative to other psychiatric disorders, anxiety disorders tend to emerge early in life, supporting the importance...
6.
Kenwood M, Oler J, Tromp D, Fox A, Riedel M, Roseboom P, et al.
Oxf Open Neurosci
. 2023 Aug;
2.
PMID: 37583705
Anxious temperament, characterized by heightened behavioral and physiological reactivity to potential threat, is an early childhood risk factor for the later development of stress-related psychopathology. Using a well-validated nonhuman primate...
7.
Aggarwal N, Oler J, Tromp D, Roseboom P, Riedel M, Elam V, et al.
Neuropsychopharmacology
. 2023 Jul;
49(2):405-413.
PMID: 37516801
Myelination subserves efficient neuronal communication, and alterations in white matter (WM) microstructure have been implicated in numerous psychiatric disorders, including pathological anxiety. Recent work in rodents suggests that muscarinic antagonists...
8.
Mueller S, Oler J, Roseboom P, Aggarwal N, Kenwood M, Riedel M, et al.
bioRxiv
. 2023 Jun;
PMID: 37333300
Anxiety disorders are among the most prevalent psychiatric disorders, with symptoms often beginning early in life. To model the pathophysiology of human pathological anxiety, we utilized Designer Receptors Exclusively Activated...
9.
Roseboom P, Mueller S, Oler J, Fox A, Riedel M, Elam V, et al.
Mol Ther
. 2021 Apr;
29(12):3484-3497.
PMID: 33895327
Non-human primate (NHP) models are essential for developing and translating new treatments that target neural circuit dysfunction underlying human psychopathology. As a proof-of-concept for treating neuropsychiatric disorders, we used a...
10.
Kovner R, Souaiaia T, Fox A, French D, Goss C, Roseboom P, et al.
Biol Psychiatry
. 2020 Jul;
88(8):638-648.
PMID: 32709417
Background: Children exhibiting extreme anxious temperament (AT) are at an increased risk for developing anxiety and depression. Our previous mechanistic and neuroimaging work in young rhesus monkeys linked the central...