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Patrick Giavalisco

Explore the profile of Patrick Giavalisco including associated specialties, affiliations and a list of published articles. Areas
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Articles 138
Citations 4695
Followers 0
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Recent Articles
1.
Tutas J, Tolve M, Ozer-Yildiz E, Ickert L, Klein I, Silverman Q, et al.
Nat Metab . 2025 Jan; 7(2):297-320. PMID: 39815080
Dysfunctions in autophagy, a cellular mechanism for breaking down components within lysosomes, often lead to neurodegeneration. The specific mechanisms underlying neuronal vulnerability due to autophagy dysfunction remain elusive. Here we...
2.
Muller-Eigner A, Gille B, Dethloff F, Meng C, Ludwig C, Heiker J, et al.
PLoS One . 2024 Dec; 19(12):e0315892. PMID: 39700228
Butyrate has been proposed as a drug therapy by acting as a lysine deacetylase (KDAC) inhibitor and elevating protein acetylation, in particular on histones. Nonetheless, recent studies suggest that tissues...
3.
Boix J, Knuever J, Niehoff N, Sen A, Pla-Martin D, Baris O, et al.
J Invest Dermatol . 2024 Nov; PMID: 39580109
Epidermis is one of the most rapidly proliferating tissues in the body with high demands for adenosine triphosphate and cellular building blocks. In this study, we show that to meet...
4.
Garcia B, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, et al.
EMBO J . 2024 Oct; 43(23):5837-5856. PMID: 39433901
The mevalonate pathway produces essential lipid metabolites such as cholesterol. Although this pathway is negatively regulated by metabolic intermediates, little is known of the metabolites that positively regulate its activity....
5.
Aich A, Boshnakovska A, Witte S, Gall T, Unthan-Fechner K, Yousefi R, et al.
Nat Commun . 2024 Aug; 15(1):6914. PMID: 39134548
Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since core...
6.
Jiang S, Yuan T, Rosenberger F, Mourier A, Dragano N, Kremer L, et al.
Nat Metab . 2024 Apr; 6(6):1024-1035. PMID: 38689023
The oxidative phosphorylation system in mammalian mitochondria plays a key role in transducing energy from ingested nutrients. Mitochondrial metabolism is dynamic and can be reprogrammed to support both catabolic and...
7.
Nikopoulou C, Kleinenkuhnen N, Parekh S, Sandoval T, Ziegenhain C, Schneider F, et al.
Nat Aging . 2023 Nov; 3(11):1430-1445. PMID: 37946043
Tissues within an organism and even cell types within a tissue can age with different velocities. However, it is unclear whether cells of one type experience different aging trajectories within...
8.
Grotehans N, McGarry L, Nolte H, Xavier V, Kroker M, Narbona-Perez A, et al.
EMBO J . 2023 Jul; 42(18):e113256. PMID: 37439264
Replication of the mitochondrial genome and expression of the genes it encodes both depend on a sufficient supply of nucleotides to mitochondria. Accordingly, dysregulated nucleotide metabolism not only destabilises the...
9.
Aarabi F, Salem M, Arrivault S, Bulut M, Schottler M, Giavalisco P, et al.
Plant Mol Biol . 2023 Jun; 112(4-5):195-198. PMID: 37347368
No abstract available.
10.
Motori E, Giavalisco P
Methods Mol Biol . 2023 May; 2675:181-194. PMID: 37258764
Feeding of stable C-labeled compounds coupled to mass spectrometric analysis has enabled the characterization of dynamic metabolite partitioning in various experimental conditions. This information is particularly relevant for the study...