Patrick Fickers
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Explore the profile of Patrick Fickers including associated specialties, affiliations and a list of published articles.
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76
Citations
956
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Recent Articles
1.
Guruk M, Fickers P, Agirman B, Darici M, Erten H
Food Sci Nutr
. 2025 Feb;
13(2):e70058.
PMID: 39968213
Sulfur dioxide (SO) is the most common additive used in winemaking with its antimicrobial and antioxidant properties. However, in recent years, there has been an increasing tendency to reduce the...
2.
Bustos C, Berrios J, Fickers P
Microb Biotechnol
. 2024 Oct;
17(10):e70022.
PMID: 39374140
In Komagataella phaffii (Pichia pastoris), formate is a recognized alternative inducer to methanol for expression systems based on the AOX1 promoter (pAOX1). By disrupting the formate dehydrogenase encoding FDH1 gene,...
3.
Liu F, Tian J, Wang Y, Zhao L, Liu Z, Chen J, et al.
Yeast
. 2024 Sep;
41(10):605-614.
PMID: 39262092
Engineering the glycerol-3-phosphate pathway could enhance erythritol production by accelerating glycerol uptake. However, little work has been conducted on the alternative dihydroxyacetone (DHA) pathway in Yarrowia lipolytica. Herein, this route...
4.
Do D, Guruk M, Kus-Liskiewicz M, Damblon C, Arguelles-Arias A, Erten H, et al.
Biotechnol J
. 2024 Feb;
19(2):e2300564.
PMID: 38403441
The dipeptide γ-glutamylcysteine (γ-GC), the first intermediate of glutathione (GSH) synthesis, is considered as a promising drug to reduce or prevent plethora of age-related disorders such as Alzheimer and Parkinson...
5.
Velastegui E, Quezada J, Altamirano C, Berrios J, Fickers P
J Biotechnol
. 2023 Jun;
373:20-23.
PMID: 37379887
The loss of mixing efficiency inherent to bioreactor process operated at large-scale yields to the formation of concentration gradient and thus to heterogeneous culture conditions. For processes operated with methanol...
6.
Velastegui E, Quezada J, Guerrero K, Altamirano C, Martinez J, Berrios J, et al.
Appl Microbiol Biotechnol
. 2023 Feb;
107(7-8):2223-2233.
PMID: 36843194
Culture medium heterogeneity is inherent in industrial bioreactors. The loss of mixing efficiency in a large-scale bioreactor yields to the formation of concentration gradients. Consequently, cells face oscillatory culture conditions...
7.
Berrios J, Theron C, Steels S, Ponce B, Velastegui E, Bustos C, et al.
Microorganisms
. 2022 Jul;
10(7).
PMID: 35889185
(aka ) is a yeast able to grow in methanol as the sole carbon and energy source. This substrate is converted into formaldehyde, a toxic intermediary that can either be...
8.
Bustos C, Quezada J, Veas R, Altamirano C, Braun-Galleani S, Fickers P, et al.
Metabolites
. 2022 Apr;
12(4).
PMID: 35448535
(formerly known as ) has become an increasingly important microorganism for recombinant protein production. This yeast species has gained high interest in an industrial setting for the production of a...
9.
Gorczyca M, Kazmierczak J, Fickers P, Celinska E
Int J Mol Sci
. 2022 Apr;
23(7).
PMID: 35408958
While overproduction of recombinant secretory proteins (rs-Prots) triggers multiple changes in the physiology of the producer cell, exposure to suboptimal growth conditions may further increase that biological response. The environmental...
10.
Ata O, Gunduz Ergun B, Fickers P, Heistinger L, Mattanovich D, Rebnegger C, et al.
FEMS Yeast Res
. 2021 Dec;
21(8).
PMID: 34849756
The important industrial protein production host Komagataella phaffii (syn Pichia pastoris) is classified as a non-conventional yeast. But what exactly makes K. phaffii non-conventional? In this review, we set out...