Patrick F Suthers
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Explore the profile of Patrick F Suthers including associated specialties, affiliations and a list of published articles.
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23
Citations
709
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Recent Articles
1.
Schroeder W, Suthers P, Willis T, Mooney E, Maranas C
Metabolites
. 2024 Jul;
14(7).
PMID: 39057688
Stoichiometric genome-scale metabolic models (generally abbreviated GSM, GSMM, or GEM) have had many applications in exploring phenotypes and guiding metabolic engineering interventions. Nevertheless, these models and predictions thereof can become...
2.
Hu M, Suthers P, Maranas C
Metab Eng
. 2024 Feb;
82:123-133.
PMID: 38336004
Large-scale kinetic models provide the computational means to dynamically link metabolic reaction fluxes to metabolite concentrations and enzyme levels while also conforming to substrate level regulation. However, the development of...
3.
Wu Z, Sun W, Shen Y, Pratas J, Suthers P, Hsieh P, et al.
Metab Eng Commun
. 2023 Mar;
16:e00220.
PMID: 36860699
Methyl methacrylate (MMA) is an important petrochemical with many applications. However, its manufacture has a large environmental footprint. Combined biological and chemical synthesis (semisynthesis) may be a promising alternative to...
4.
Hu M, Dinh H, Shen Y, Suthers P, Foster C, Call C, et al.
Metab Eng
. 2023 Jan;
76:1-17.
PMID: 36603705
The parameterization of kinetic models requires measurement of fluxes and/or metabolite levels for a base strain and a few genetic perturbations thereof. Unlike stoichiometric models that are mostly invariant to...
5.
Suthers P, Maranas C
Biotechnol Prog
. 2022 May;
38(5):e3276.
PMID: 35603544
Growth-coupling product formation can facilitate strain stability by aligning industrial objectives with biological fitness. Organic acids make up many building block chemicals that can be produced from sugars obtainable from...
6.
Foster C, Wang L, Dinh H, Suthers P, Maranas C
Curr Opin Biotechnol
. 2020 Dec;
67:35-41.
PMID: 33360621
Kinetic formalisms of metabolism link metabolic fluxes to enzyme levels, metabolite concentrations and their allosteric regulatory interactions. Though they require the identification of physiologically relevant values for numerous parameters, kinetic...
7.
Suthers P, Foster C, Sarkar D, Wang L, Maranas C
Metab Eng
. 2020 Dec;
63:13-33.
PMID: 33310118
Understanding the governing principles behind organisms' metabolism and growth underpins their effective deployment as bioproduction chassis. A central objective of metabolic modeling is predicting how metabolism and growth are affected...
8.
Suthers P, Dinh H, Fatma Z, Shen Y, Chan S, Rabinowitz J, et al.
Metab Eng Commun
. 2020 Nov;
11:e00148.
PMID: 33134082
Many platform chemicals can be produced from renewable biomass by microorganisms, with organic acids making up a large fraction. Intolerance to the resulting low pH growth conditions, however, remains a...
9.
Dinh H, Suthers P, Chan S, Shen Y, Xiao T, Deewan A, et al.
Metab Eng Commun
. 2019 Nov;
9:e00101.
PMID: 31720216
is a red, basidiomycetes yeast that can accumulate a large amount of lipids and produce carotenoids. To better assess this non-model yeast's metabolic capabilities, we reconstructed a genome-scale model of...
10.
Zomorrodi A, Suthers P, Ranganathan S, Maranas C
Metab Eng
. 2012 Oct;
14(6):672-86.
PMID: 23026121
Genome-scale metabolic models are increasingly becoming available for a variety of microorganisms. This has spurred the development of a wide array of computational tools, and in particular, mathematical optimization approaches,...