Patrick F J Fuchs
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Explore the profile of Patrick F J Fuchs including associated specialties, affiliations and a list of published articles.
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30
Citations
581
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Recent Articles
1.
Versini R, Baaden M, Cavellini L, Cohen M, Taly A, Fuchs P
Structure
. 2024 Sep;
32(11):1997-2012.e7.
PMID: 39299234
Outer mitochondrial membrane fusion, a vital cellular process, is mediated by mitofusins. However, the underlying molecular mechanism remains elusive. We have performed extensive multiscale molecular dynamics simulations to predict a...
2.
Kiirikki A, Antila H, Bort L, Buslaev P, Favela-Rosales F, Mendes Ferreira T, et al.
Nat Commun
. 2024 Feb;
15(1):1136.
PMID: 38326316
Tools based on artificial intelligence (AI) are currently revolutionising many fields, yet their applications are often limited by the lack of suitable training data in programmatically accessible format. Here we...
3.
Carlier L, Samson D, Khemtemourian L, Joliot A, Fuchs P, Lequin O
Biochim Biophys Acta Biomembr
. 2022 Aug;
1864(11):184030.
PMID: 35988722
Homeoprotein transcription factors have the property of interacting with membranes through their DNA-binding homeodomain, which is involved in unconventional internalization and secretion. Both processes depend on membrane-translocating events but their...
4.
Bechtella L, Chalouhi E, Milan Rodriguez P, Cosset M, Ravault D, Illien F, et al.
ACS Chem Biol
. 2022 May;
17(6):1427-1439.
PMID: 35608167
Cell-penetrating peptides cross cell membranes through various parallel internalization pathways. Herein, we analyze the role of the negatively charged lipid phosphatidylinositol-4,5-bisphosphate (PI(4,5)P) in the internalization of Penetratin. Contributions of both...
5.
Francois-Martin C, Bacle A, Rothman J, Fuchs P, Pincet F
Front Mol Biosci
. 2021 Nov;
8:763115.
PMID: 34746239
The shape of lipids has long been suspected to be a critical determinant for the control of membrane fusion. To experimentally test this assertion, we used conical and malleable lipids...
6.
Bacle A, Buslaev P, Garcia-Fandino R, Favela-Rosales F, Mendes Ferreira T, Fuchs P, et al.
J Am Chem Soc
. 2021 Sep;
143(34):13701-13709.
PMID: 34465095
Interest in lipid interactions with proteins and other biomolecules is emerging not only in fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly used, for example,...
7.
El Hajj F, Fuchs P, Urbach W, Nassereddine M, Hamieh S, Taulier N
Langmuir
. 2021 Mar;
37(13):3868-3881.
PMID: 33769822
Several investigations have suggested that ultrasound triggers the release of drugs encapsulated into liposomes at acoustic pressures low enough to avoid cavitation or high hyperthermia. However, the mechanism leading to...
8.
van Gunsteren W, Daura X, Fuchs P, Hansen N, Horta B, Hunenberger P, et al.
Chemphyschem
. 2020 Dec;
22(3):264-282.
PMID: 33377305
Computer simulations of molecular systems enable structure-energy-function relationships of molecular processes to be described at the sub-atomic, atomic, supra-atomic or supra-molecular level and plays an increasingly important role in chemistry,...
9.
Jobin M, Vamparys L, Deniau R, Grelard A, Mackereth C, Fuchs P, et al.
Int J Mol Sci
. 2019 Sep;
20(18).
PMID: 31505894
Cell-penetrating peptides (CPPs) are short peptides that can translocate and transport cargoes into the intracellular milieu by crossing biological membranes. The mode of interaction and internalization of cell-penetrating peptides has...
10.
Senac C, Desgranges S, Contino-Pepin C, Urbach W, Fuchs P, Taulier N
ACS Omega
. 2019 Aug;
3(1):1014-1021.
PMID: 31457945
Most therapeutic targets are proteins whose binding sites are hydrophobic cavities. For this reason, the majority of drugs under development are hydrophobic molecules exhibiting low solubility in water. To tackle...