Patrick Collombat
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Explore the profile of Patrick Collombat including associated specialties, affiliations and a list of published articles.
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2136
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Recent Articles
1.
Oger F, Bourouh C, Friano M, Courty E, Rolland L, Gromada X, et al.
Diabetes
. 2023 May;
72(8):1112-1126.
PMID: 37216637
Article Highlights: β-Cell-specific E2f1 deficiency in mice impairs glucose tolerance. Loss of E2f1 function alters the ratio of α- to β-cells but does not trigger β-cell conversion into α-cells. Pharmacological...
2.
Napolitano T, Silvano S, Ayachi C, Plaisant M, Sousa-Da-Veiga A, Fofo H, et al.
Cells
. 2023 Feb;
12(4).
PMID: 36831232
The pancreas is an abdominal gland that serves 2 vital purposes: assist food processing by secreting digestive enzymes and regulate blood glucose levels by releasing endocrine hormones. During embryonic development,...
3.
Garrido-Utrilla A, Ayachi C, Friano M, Atlija J, Balaji S, Napolitano T, et al.
Front Endocrinol (Lausanne)
. 2022 May;
13:861922.
PMID: 35573999
Type 1 diabetes results from the autoimmune-mediated loss of insulin-producing beta-cells. Accordingly, important research efforts aim at regenerating these lost beta-cells by converting pre-existing endogenous cells. Following up on previous...
4.
Napolitano T, Avolio F, Silvano S, Forcisi S, Pfeifer A, Vieira A, et al.
Cells
. 2021 Nov;
10(11).
PMID: 34831029
Although several approaches have revealed much about individual factors that regulate pancreatic development, we have yet to fully understand their complicated interplay during pancreas morphogenesis. Gfi1 is transcription factor specifically...
5.
Khurana I, Al-Hasani K, Maxwell S, K N H, Okabe J, Cooper M, et al.
NPJ Regen Med
. 2021 Feb;
6(1):7.
PMID: 33580013
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are...
6.
Marquina-Sanchez B, Fortelny N, Farlik M, Vieira A, Collombat P, Bock C, et al.
Genome Biol
. 2020 May;
21(1):106.
PMID: 32375897
Background: Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool to dissect cell-specific effects of drug treatment in complex tissues. This application requires high levels of precision, robustness, and quantitative...
7.
Poeta L, Padula A, Attianese B, Valentino M, Verrillo L, Filosa S, et al.
Hum Mol Genet
. 2019 Nov;
28(24):4089-4102.
PMID: 31691806
A disproportional large number of neurodevelopmental disorders (NDDs) is caused by variants in genes encoding transcription factors and chromatin modifiers. However, the functional interactions between the corresponding proteins are only...
8.
Napolitano T, Silvano S, Vieira A, Balaji S, Garrido-Utrilla A, Friano M, et al.
Diabetes Obes Metab
. 2018 Sep;
20 Suppl 2:3-10.
PMID: 30230184
Ghrelin is a gastric peptide with anabolic functions. It acutely stimulates growth hormone (GH) secretion from the anterior pituitary glands and modulates hypothalamic circuits that control food intake and energy...
9.
Balaji S, Napolitano T, Silvano S, Friano M, Garrido-Utrilla A, Atlija J, et al.
Genes (Basel)
. 2018 Sep;
9(9).
PMID: 30205460
Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells...
10.
Vieira A, Vergoni B, Courtney M, Druelle N, Gjernes E, Hadzic B, et al.
PLoS One
. 2018 Aug;
13(8):e0201536.
PMID: 30092080
In the context of type 1 diabetes research and the development of insulin-producing β-cell replacement strategies, whether pancreatic ductal cells retain their developmental capability to adopt an endocrine cell identity...