Patrick B Lappin
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Explore the profile of Patrick B Lappin including associated specialties, affiliations and a list of published articles.
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18
Citations
785
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Recent Articles
1.
Martinez R, Blasina A, Hallin J, Hu W, Rymer I, Fan J, et al.
PLoS One
. 2015 Sep;
10(9):e0138616.
PMID: 26398286
Cell cycle checkpoint intervention is an effective therapeutic strategy for cancer when applied to patients predisposed to respond and the treatment is well-tolerated. A critical cell cycle process that could...
2.
Zou H, Friboulet L, Kodack D, Engstrom L, Li Q, West M, et al.
Cancer Cell
. 2015 Jul;
28(1):70-81.
PMID: 26144315
We report the preclinical evaluation of PF-06463922, a potent and brain-penetrant ALK/ROS1 inhibitor. Compared with other clinically available ALK inhibitors, PF-06463922 displayed superior potency against all known clinically acquired ALK...
3.
Zou H, Li Q, Engstrom L, West M, Appleman V, Wong K, et al.
Proc Natl Acad Sci U S A
. 2015 Mar;
112(11):3493-8.
PMID: 25733882
Oncogenic c-ros oncogene1 (ROS1) fusion kinases have been identified in a variety of human cancers and are attractive targets for cancer therapy. The MET/ALK/ROS1 inhibitor crizotinib (Xalkori, PF-02341066) has demonstrated...
4.
Zhang C, Yan Z, Giddabasappa A, Lappin P, Painter C, Zhang Q, et al.
Cancer Med
. 2014 Feb;
3(3):462-71.
PMID: 24573979
Noninvasive imaging has been widely applied for monitoring antiangiogenesis therapy in cancer drug discovery. In this report, we used different imaging modalities including high-frequency ultrasound (HFUS), dynamic contrast enhanced-MR (DCE-MR),...
5.
Patient-derived xenografts reveal limits to PI3K/mTOR- and MEK-mediated inhibition of bladder cancer
Cirone P, Andresen C, Eswaraka J, Lappin P, Bagi C
Cancer Chemother Pharmacol
. 2014 Jan;
73(3):525-38.
PMID: 24442130
Background: Metastatic bladder cancer is a serious condition with a 5-year survival rate of approximately 14 %, a rate that has remained unchanged for almost three decades. Thus, there is...
6.
Lalwani K, Giddabasappa A, Li D, Olson P, Simmons B, Shojaei F, et al.
Comp Med
. 2013 Dec;
63(6):482-90.
PMID: 24326223
The identification and quantitative evaluation of lung tumors in mouse models is challenging and an unmet need in preclinical arena. In this study, we developed a noninvasive contrast-enhanced microCT (μCT)...
7.
Fang D, Zhang C, Gu Y, Jani J, Cao J, Tsaparikos K, et al.
PLoS One
. 2013 Jul;
8(6):e67258.
PMID: 23826249
PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide) mutations can help predict the antitumor activity of phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway inhibitors in both preclinical and clinical settings. In light of...
8.
Kakiuchi-Kiyota S, Lappin P, Heintz C, Brown P, Pinho F, Ryan A, et al.
Appl Immunohistochem Mol Morphol
. 2013 May;
22(3):188-99.
PMID: 23702648
We performed immunohistochemistry for macrophage colony-stimulating factor 1 receptor (also known as c-fms proto-oncogene product) on tissue microarrays of human nontumor lung, pulmonary squamous cell carcinomas (SCC) and adenocarcinomas (ADC),...
9.
Zhang C, Pavlicek A, Zhang Q, Lira M, Painter C, Yan Z, et al.
Clin Cancer Res
. 2012 Jul;
18(18):5008-19.
PMID: 22806875
Purpose: We aimed to assess the biologic activity of PF-03084014 in breast xenograft models. The biomarkers for mechanism and patient stratification were also explored. Experimental Design: The in vitro and...
10.
Sacha J, Kim I, Chen L, Ullah J, Goodwin D, Simmons H, et al.
J Immunol
. 2012 Jun;
189(3):1467-79.
PMID: 22745376
The expression of endogenous retrotransposable elements, including long interspersed nuclear element 1 (LINE-1 or L1) and human endogenous retrovirus, accompanies neoplastic transformation and infection with viruses such as HIV. The...