Patrick A Murphy
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Explore the profile of Patrick A Murphy including associated specialties, affiliations and a list of published articles.
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24
Citations
446
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Recent Articles
1.
Omar O, Kimble A, Cheemala A, Tyburski J, Pandey S, Wu Q, et al.
Nat Neurosci
. 2025 Mar;
PMID: 40087396
Endothelial cells (ECs) help maintain the blood-brain barrier but deteriorate in many neurodegenerative disorders. Here we show, using a specialized method to isolate EC and microglial nuclei from postmortem human...
2.
Karginov T, Menoret A, Leclair N, Harrison A, Chandiran K, Suarez-Ramirez J, et al.
Science
. 2024 Sep;
385(6714):eadj1979.
PMID: 39265028
T cell receptor (TCR) sensitivity to peptide-major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully explained by transcriptional regulation. In this work, we...
3.
Nicholas S, Helming S, Menoret A, Pathoulas C, Xu M, Hensel J, et al.
bioRxiv
. 2024 Aug;
PMID: 39131295
Atherosclerotic plaques are defined by the accumulation of lipids and immune cells beneath the endothelium of the arterial intima. CD8 T cells are among the most abundant immune cell types...
4.
Cheemala A, Kimble A, Tyburski J, Leclair N, Zuberi A, Murphy M, et al.
bioRxiv
. 2024 Jan;
PMID: 38168388
Loss of nuclear TDP-43 occurs in a wide range of neurodegenerative diseases, and specific mutations in the gene that encodes the protein are linked to familial Frontal Temporal Lobar Dementia...
5.
Omar O, Kimble A, Cheemala A, Tyburski J, Pandey S, Wu Q, et al.
bioRxiv
. 2024 Jan;
PMID: 38168276
Despite the importance of the endothelium in the regulation of the blood brain barrier (BBB) in aging and neurodegenerative disease, difficulties in extracting endothelial cell (EC) nuclei have limited analysis...
6.
Franco-Acevedo A, Pathoulas C, Murphy P, Valenzuela N
J Immunol
. 2023 Oct;
211(9):1276-1285.
PMID: 37844279
Ab-mediated rejection of organ transplants remains a stubborn, frequent problem affecting patient quality of life, graft function, and grant survival, and for which few efficacious therapies currently exist. Although the...
7.
Hensel J, Nicholas S, Kimble A, Nagpal A, Omar O, Tyburski J, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2122227119.
PMID: 35858420
NF-κB-mediated endothelial activation drives leukocyte recruitment and atherosclerosis, in part through adhesion molecules Icam1 and Vcam1. The endothelium is primed for cytokine activation of NF-κB by exposure to low and...
8.
Li C, Qu L, Matz A, Murphy P, Liu Y, Manichaikul A, et al.
Circulation
. 2021 Dec;
145(3):206-218.
PMID: 34913723
Background: Whereas several interventions can effectively lower lipid levels in people at risk for atherosclerotic cardiovascular disease (ASCVD), cardiovascular event risks remain, suggesting an unmet medical need to identify factors...
9.
Kimble A, Silva J, Omar O, Murphy M, Hensel J, Nicholas S, et al.
Lab Invest
. 2021 Nov;
102(2):204-211.
PMID: 34775494
Endothelial cells are important contributors to brain development, physiology, and disease. Although RNA sequencing has contributed to the understanding of brain endothelial cell diversity, bulk analysis and single-cell approaches have...
10.
Hensel J, Heineman B, Kimble A, Jellison E, Reese B, Murphy P
Sci Rep
. 2021 Oct;
11(1):19835.
PMID: 34615942
The extracellular matrix protein fibronectin (FN) is alternatively spliced in a variety of inflammatory conditions, resulting in increased inclusion of alternative exons EIIIA and EIIIB. Inclusion of these exons affects...