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Patricia D A Lima

Explore the profile of Patricia D A Lima including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 30
Citations 501
Followers 0
Related Specialties
Reproductive Medicine
Physiology
Science
Top 10 Co-Authors
Stephen L Archer
Danchen Wu
Kuang-Hueih Chen
Asish Dasgupta
Jeffrey D Mewburn
Benjamin K Tsang
Francois Potus
Rachel E T Bentley
Ruaa Al-Qazazi
B Anne Croy
Published In
Biol Reprod
PLoS One
FASEB J
Cell Mol Immunol
J Am Heart Assoc
Affiliations
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Recent Articles
11.
Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility
Prisco S, Hartweck L, Rose L, Lima P, Thenappan T, Archer S, et al.
Circ Heart Fail . 2021 Dec; 15(1):e008574. PMID: 34923829
Background: Right ventricular dysfunction (RVD) is the leading cause of death in pulmonary arterial hypertension (PAH), but no RV-specific therapy exists. We showed microtubule-mediated junctophilin-2 dysregulation (MT-JPH2 pathway) causes t-tubule...
12.
PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension
Dasgupta A, Chen K, Lima P, Mewburn J, Wu D, Al-Qazazi R, et al.
FASEB J . 2021 Jul; 35(8):e21771. PMID: 34275172
Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression, contributes to unrestricted cell proliferation and apoptosis-resistance in hyperproliferative diseases like pulmonary arterial hypertension (PAH) and non-small cell...
13.
The molecular mechanisms of oxygen-sensing in human ductus arteriosus smooth muscle cells: A comprehensive transcriptome profile reveals a central role for mitochondria
Bentley R, Hindmarch C, Dunham-Snary K, Snetsinger B, Mewburn J, Thebaud A, et al.
Genomics . 2021 Jul; 113(5):3128-3140. PMID: 34245829
The ductus arteriosus (DA) connects the fetal pulmonary artery and aorta, diverting placentally oxygenated blood from the developing lungs to the systemic circulation. The DA constricts in response to increases...
14.
Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion
Tian L, Xiong P, Alizadeh E, Lima P, Potus F, Mewburn J, et al.
Acta Physiol (Oxf) . 2020 Apr; 229(4):e13483. PMID: 32339403
Aim: Pulmonary arterial hypertension (PAH) results in right ventricular (RV) dysfunction owing, in part, to RV ischemia. The relative contribution of RV microvascular rarefaction vs reduced right coronary artery perfusion...
15.
Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis
Tian L, Wu D, Dasgupta A, Chen K, Mewburn J, Potus F, et al.
Circ Res . 2020 Mar; 126(12):1723-1745. PMID: 32216531
Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts (RVfib), these cells are understudied....
16.
An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications
Dasgupta A, Chen K, Wu D, Hoskin V, Mewburn J, Lima P, et al.
FASEB J . 2020 Feb; 34(4):5106-5127. PMID: 32068312
Excessive proliferation and apoptosis-resistance are hallmarks of cancer. Increased dynamin-related protein 1 (Drp1)-mediated mitochondrial fission is one of the mediators of this phenotype. Mitochondrial fission that accompanies the nuclear division...
17.
Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner
Urata Y, Salehi R, Lima P, Osuga Y, Tsang B
J Ovarian Res . 2020 Jan; 13(1):5. PMID: 31915051
Background: The complex regulatory mechanism involved in ovarian follicular development is not completely understood. Neuronal neuropeptide Y (NPY) is involved in the regulation of feeding behavior, energy homeostasis, and reproduction...
18.
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury
Wu D, Dasgupta A, Chen K, Neuber-Hess M, Patel J, Hurst T, et al.
FASEB J . 2020 Jan; 34(1):1447-1464. PMID: 31914641
Mitochondrial fission is important in physiological processes, including coordination of mitochondrial and nuclear division during mitosis, and pathologic processes, such as the production of reactive oxygen species (ROS) during cardiac...
19.
Polycystic ovary syndrome: possible involvement of androgen-induced, chemerin-mediated ovarian recruitment of monocytes/macrophages
Lima P, Nivet A, Wang Q, Chen Y, Leader A, Cheung A, et al.
Biol Reprod . 2018 Apr; 99(4):838-852. PMID: 29688269
Polycystic ovary syndrome (PCOS) is a continuum of endocrine and reproductive disorders characterized by hyperandrogenism, antral follicle growth arrest, and chronic inflammation. Macrophages play key role in inflammation, and the...
20.
Surface-enhanced Raman scattering for the detection of polycystic ovary syndrome
Momenpour A, Lima P, Chen Y, Tzeng C, Tsang B, Anis H
Biomed Opt Express . 2018 Mar; 9(2):801-817. PMID: 29552414
Polycystic ovary syndrome (PCOS) is a multi-factorial heterogeneous syndrome that affects many women of reproductive age. This work demonstrates how the surface-enhanced Raman scattering (SERS) technique can be used to...