Patricia Coutinho de Souza
Overview
Explore the profile of Patricia Coutinho de Souza including associated specialties, affiliations and a list of published articles.
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12
Citations
133
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0
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Recent Articles
1.
Loo J, Robbins M, McNeil C, Yoshitake T, Santori C, Shan C, et al.
Cancer Res Commun
. 2024 Dec;
5(1):54-65.
PMID: 39636222
We extend the capabilities of virtual staining from AF to a different disease and stain modality. Our work includes newly developed virtual stains for H&E and a multiplex immunofluorescence panel...
2.
Dou Q, Grant A, Callahan C, Coutinho de Souza P, Mwin D, Booth A, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Sep;
15(1):61-75.
PMID: 36162723
Background & Aims: Metabolic reprogramming, in particular, glycolytic regulation, supports abnormal survival and growth of hepatocellular carcinoma (HCC) and could serve as a therapeutic target. In this study, we sought...
3.
Varma G, Seth P, Coutinho de Souza P, Callahan C, Pinto J, Vaidya M, et al.
NMR Biomed
. 2021 Jun;
34(8):e4560.
PMID: 34086382
In many tumors, cancer cells take up large quantities of glucose and metabolize it into lactate, even in the presence of sufficient oxygen to support oxidative metabolism. It has been...
4.
Goodwin J, Tsai L, Mwin D, Coutinho de Souza P, Dialani S, Moon J, et al.
Magn Reson Imaging
. 2021 Apr;
80:90-97.
PMID: 33901585
Purpose: Hepatic thermal ablation therapy can result in c-Met-mediated off-target stimulation of distal tumor growth. The purpose of this study was to determine if a similar effect on tumor metabolism...
5.
Towner R, Smith N, Saunders D, Brown C, Cai X, Ziegler J, et al.
Transl Oncol
. 2018 Nov;
12(2):320-335.
PMID: 30468988
Treatment of glioblastoma (GBM) remains a challenge using conventional chemotherapy, such as temozolomide (TMZ), and is often ineffective as a result of drug resistance. We have assessed a novel nitrone-based...
6.
Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, et al.
Neuro Oncol
. 2016 Jul;
19(2):175-185.
PMID: 27416955
Background: Despite current therapies, glioblastoma is a devastating cancer, and validation of effective biomarkers for it will enable better diagnosis and therapeutic intervention for this disease. We recently discovered a...
7.
Coutinho de Souza P, Smith N, Pody R, He T, Njoku C, Silasi-Mansat R, et al.
Am J Nucl Med Mol Imaging
. 2015 Aug;
5(4):363-78.
PMID: 26269774
Angiogenesis is essential to tumor progression, and the precise imaging of the angiogenic marker vascular endothelial growth factor receptor 2 (VEGFR-2) may provide an accurate evaluation for angiogenesis during a...
8.
Coutinho de Souza P, Mallory S, Smith N, Saunders D, Li X, McNall-Knapp R, et al.
PLoS One
. 2015 Aug;
10(8):e0134276.
PMID: 26248280
Pediatric glioblastomas (pGBM), although rare, are one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. Here, we describe the use of conventional...
9.
Coutinho de Souza P, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, et al.
Free Radic Biol Med
. 2015 Jun;
87:157-68.
PMID: 26119786
Free radicals are associated with glioma tumors. Here, we report on the ability of an anticancer nitrone compound, OKN-007 [Oklahoma Nitrone 007; a disulfonyl derivative of α-phenyl-tert-butyl nitrone (PBN)] to...
10.
Coutinho de Souza P, Ranjan A, Towner R
Nanomedicine (Lond)
. 2015 May;
10(9):1515-34.
PMID: 25996122
Pancreatic and liver cancers often have poor prognoses. Clinically, pancreatic and liver cancer requires early diagnosis, and surgery is often associated with tumor recurrence. Currently, chemotherapies are limited in their...