Debra Saunders
Overview
Explore the profile of Debra Saunders including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
843
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Recent Articles
1.
Elayapillai S, Gandhi A, Dogra S, Saunders D, Smith N, Hladik C, et al.
J Pharmacol Exp Ther
. 2025 Feb;
392(1):100004.
PMID: 39893009
Advanced-stage endometrial cancer patients typically receive a combination of platinum and paclitaxel chemotherapy. However, limited treatment options are available for those with recurrent disease, and there is a need to...
2.
Heidebrecht Jr R, Jozefiak T, Shain H, Skrabut E, Saunders D, Smith N, et al.
PLoS One
. 2025 Jan;
20(1):e0317790.
PMID: 39854411
Chemical modification of naturally derived glycosaminoglycans (GAGs) expands their potential utility for applications in soft tissue repair and regenerative medicine. Here we report the preparation of a novel crosslinked chondroitin...
3.
Bhaskaran S, Piekarz K, Brown J, Yang B, Ocanas S, Wren J, et al.
Front Neurosci
. 2024 Dec;
18:1505369.
PMID: 39633896
Our study investigated the therapeutic potential of OKN-007 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS). The impact of OKN-007, known for its antioxidant, anti-inflammatory, and neuroprotective...
4.
Bhaskaran S, Kumar G, Thadathil N, Piekarz K, Mohammed S, Lopez S, et al.
Redox Biol
. 2022 Dec;
59():102550.
PMID: 36470129
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease. Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord by deletion of Mn-Superoxide dismutase...
5.
Melek M, Towner R, Kung J, Saunders D, Zales M, Bhatti F
J Vis Exp
. 2022 Nov;
(188).
PMID: 36373906
Perinatal hypoxic-ischemic encephalopathy (HIE) is an acute disease that may afflict newborns, resulting in variable long- and short-term neurodevelopmental outcomes. Early diagnosis is critical to identifying infants who may benefit...
6.
Towner R, Zalles M, Saunders D, Smith N
Cancer Drug Resist
. 2022 May;
3(4):686-698.
PMID: 35582224
The poor prognosis of glioblastoma multiforme (GBM) patients is in part due to resistance to current standard-of-care treatments including chemotherapy [predominantly temozolomide (TMZ; Temodar)], radiation therapy and an anti-angiogenic therapy...
7.
Dang T, Lerner M, Saunders D, Smith N, Gulej R, Zalles M, et al.
Cells
. 2022 May;
11(9).
PMID: 35563787
One of the major obstacles in treating brain cancers, particularly glioblastoma multiforme, is the occurrence of secondary tumor lesions that arise in areas of the brain and are inoperable while...
8.
Towner R, Hocker J, Smith N, Saunders D, Battiste J, Hanas J
Brain Sci
. 2022 Jan;
12(1).
PMID: 35053843
Current therapies for high-grade gliomas, particularly glioblastomas (GBM), do not extend patient survival beyond 16-22 months. OKN-007 (OKlahoma Nitrone 007), which is currently in phase II (multi-institutional) clinical trials for...
9.
Towner R, Smith N, Saunders D, Hurst R
Diagnostics (Basel)
. 2021 Dec;
11(12).
PMID: 34943535
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic, often incapacitating condition characterized by pain seeming to originate in the bladder in conjunction with lower urinary tract symptoms of frequency and...
10.
Zalles M, Smith N, Saunders D, Lerner M, Fung K, Battiste J, et al.
J Cell Mol Med
. 2021 Dec;
26(2):570-582.
PMID: 34910361
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Despite a multimodal treatment response, survival for GBM patients remains between 12 and 15 months. Anti-ELTD1 antibody therapy...