Patricia A Kosian
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Explore the profile of Patricia A Kosian including associated specialties, affiliations and a list of published articles.
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31
Citations
319
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Recent Articles
1.
Ford J, Riutta C, Kosian P, OShaughessy K, Gilbert M
Toxicol Sci
. 2023 Apr;
193(2):192-203.
PMID: 37099719
A number of xenobiotics interfere with thyroid hormone (TH) signaling. Although adequate supplies of TH are necessary for normal brain development, regulatory reliance on serum TH as proxies for brain...
2.
Haselman J, Olker J, Kosian P, Korte J, Denny J, Tietge J, et al.
Toxicol Sci
. 2022 Feb;
187(1):139-149.
PMID: 35179606
Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical activity...
3.
Haselman J, Olker J, Kosian P, Korte J, Swintek J, Denny J, et al.
Toxicol Sci
. 2020 Mar;
175(2):236-250.
PMID: 32176285
Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift...
4.
Serrano J, Kolanczyk R, Tapper M, Lahren T, Dongari N, Hammermeister D, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2019 Aug;
1126-1127:121717.
PMID: 31437775
Cyclic phenones are chemicals of interest to the USEPA and international organizations due to their potential for endocrine disruption to aquatic and terrestrial species. The metabolic conversion of cyclic phenones...
5.
Serrano J, Tapper M, Kolanczyk R, Sheedy B, Lahren T, Hammermeister D, et al.
Xenobiotica
. 2019 Mar;
50(2):192-208.
PMID: 30888238
1. Cyclic phenones are chemicals of interest to the USEPA due to their potential for endocrine disruption to aquatic and terrestrial species.2. Prior to this report, there was very limited...
6.
Olker J, Haselman J, Kosian P, Donnay K, Korte J, Blanksma C, et al.
Toxicol Sci
. 2018 Aug;
166(2):318-331.
PMID: 30137636
The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells. Loss of function or chemical inhibition of IYD reduces available iodide for thyroid...
7.
OShaughnessy K, Wood C, Ford R, Kosian P, Hotchkiss M, Degitz S, et al.
Toxicol Sci
. 2018 Aug;
166(1):163-179.
PMID: 30085217
Adverse neurodevelopmental consequences remain a primary concern when evaluating the effects of thyroid hormone (TH) disrupting chemicals. Though the developing brain is a known target of TH insufficiency, the relationship...
8.
Haselman J, Kosian P, Korte J, Olmstead A, Degitz S
Aquat Toxicol
. 2018 Apr;
199:240-251.
PMID: 29674245
The Larval Amphibian Growth and Development Assay (LAGDA) is an internationally harmonized testing guideline for evaluating effects of chronic chemical exposure in amphibians. In order to evaluate the effects of...
9.
OShaughnessy K, Kosian P, Ford J, Oshiro W, Degitz S, Gilbert M
Toxicol Sci
. 2018 Feb;
163(1):101-115.
PMID: 29385626
Thyroid hormones (THs) are essential for brain development, but few rodent models exist that link TH inefficiency to apical neurodevelopmental endpoints. We have previously described a structural anomaly, a heterotopia,...
10.
Hassan I, El-Masri H, Kosian P, Ford J, Degitz S, Gilbert M
Toxicol Sci
. 2017 Oct;
160(1):57-73.
PMID: 28973696
Adequate levels of thyroid hormone (TH) are needed for proper brain development, deficiencies may lead to adverse neurologic outcomes in humans and animal models. Environmental chemicals have been linked to...