Patricia A Escobar
Overview
Explore the profile of Patricia A Escobar including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
211
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0
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Recent Articles
1.
Escobar P, Sobol Z, Miller R, Ferry-Martin S, Stermer A, Jacob B, et al.
Toxicol Sci
. 2024 Dec;
204(1):118-119.
PMID: 39693107
No abstract available.
2.
Luijten M, van Benthem J, Morita T, Corvi R, Escobar P, Fujita Y, et al.
Environ Mol Mutagen
. 2024 Dec;
PMID: 39628086
In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all...
3.
Escobar P, Sobol Z, Miller R, Ferry-Martin S, Stermer A, Jacob B, et al.
Toxicol Sci
. 2024 Sep;
202(2):278-290.
PMID: 39302733
Molnupiravir is registered or authorized in several countries as a 5-d oral coronavirus disease 2019 treatment for adults. Molnupiravir is a prodrug of the antiviral ribonucleoside β-D-N4-hydroxycytidine (NHC) that distributes...
4.
Powley M, Sobol Z, Johnson G, Clark R, Dalby S, Ykoruk B, et al.
Regul Toxicol Pharmacol
. 2024 Jul;
152:105681.
PMID: 39067806
The finding of N-nitrosodiethylamine (NDEA) and N-nitrosodimethylamine (NDMA) in marketed drugs has led to implementation of risk assessment processes intended to limit exposures to the entire class of N-nitrosamines. A...
5.
Bercu J, Zhang S, Sobol Z, Escobar P, Van P, Schuler M
Mutat Res Genet Toxicol Environ Mutagen
. 2023 Sep;
891:503685.
PMID: 37770142
N-Nitrosodiethylamine (NDEA), a well-studied N-nitrosamine, was tested in rats to compare the dose-response relationship of three genotoxicity endpoints. Mutant / mutation frequencies were determined using the transgenic rodent (TGR) gene...
6.
Marchetti F, Cardoso R, Chen C, Douglas G, Elloway J, Escobar P, et al.
Mutat Res Rev Mutat Res
. 2023 Aug;
792:108466.
PMID: 37643677
Error-corrected Next Generation Sequencing (ecNGS) is rapidly emerging as a valuable, highly sensitive and accurate method for detecting and characterizing mutations in any cell type, tissue or organism from which...
7.
Lynch A, Zanoni T, Salk J, Martincorena I, Young R, Kucab J, et al.
Mutagenesis
. 2023 Jun;
38(4):192-200.
PMID: 37300447
The use of error-corrected Next Generation Sequencing (ecNG) to determine mutagenicity has been a subject of growing interest and potentially a disruptive technology that could supplement, and in time, replace...
8.
Marchetti F, Cardoso R, Chen C, Douglas G, Elloway J, Escobar P, et al.
Nat Rev Drug Discov
. 2023 Jan;
22(3):165-166.
PMID: 36646809
No abstract available.
9.
Trejo-Martin A, Bercu J, Thresher A, Tennant R, Thomas R, Cross K, et al.
Regul Toxicol Pharmacol
. 2022 Aug;
135:105247.
PMID: 35998738
Under ICH M7, impurities are assessed using the bacterial reverse mutation assay (i.e., Ames test) when predicted positive using in silico methodologies followed by expert review. N-Nitrosamines (NAs) have been...
10.
Corton J, Mitchell C, Auerbach S, Bushel P, Ellinger-Ziegelbauer H, Escobar P, et al.
Toxicol Sci
. 2022 Apr;
188(1):4-16.
PMID: 35404422
There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial...