Patrice Douillard
Overview
Explore the profile of Patrice Douillard including associated specialties, affiliations and a list of published articles.
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17
Citations
976
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Recent Articles
1.
Douillard P, Freissmuth M, Antoine G, Thiele M, Fleischanderl D, Matthiessen P, et al.
Antibodies (Basel)
. 2019 Sep;
8(3).
PMID: 31544852
Efficacy, safety, and manufacturability of therapeutic antibodies are influenced by their biopharmaceutical and biophysical properties. These properties can be optimized by library approaches or rationale protein design. Here, we employed...
2.
Schinagl A, Kerschbaumer R, Sabarth N, Douillard P, Scholz P, Voelkel D, et al.
Biochemistry
. 2018 Feb;
57(9):1523-1532.
PMID: 29412660
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory and tumor-promoting cytokine that occurs in two redox-dependent immunologically distinct conformational isoforms. The disease-related structural isoform of MIF (oxMIF) can be specifically...
3.
Hollriegl W, Bauer A, Baumgartner B, Dietrich B, Douillard P, Kerschbaumer R, et al.
Eur J Pharmacol
. 2017 Dec;
820:206-216.
PMID: 29274331
New therapeutic agents are needed to overcome the toxicity and suboptimal efficacy observed in current treatment of glomerulonephritis (GN). BaxB01 is a fully human monoclonal antibody targeting a disease-related immunologically...
4.
Schinagl A, Thiele M, Douillard P, Volkel D, Kenner L, Kazemi Z, et al.
Oncotarget
. 2016 Sep;
7(45):73486-73496.
PMID: 27636991
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, which was shown to be upregulated in cancers and to exhibit tumor promoting properties. Unlike other cytokines, MIF is ubiquitously present...
5.
Thiele M, Kerschbaumer R, Tam F, Volkel D, Douillard P, Schinagl A, et al.
J Immunol
. 2015 Jul;
195(5):2343-52.
PMID: 26209628
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different from other cytokines because it is constitutively expressed, stored...
6.
Hussain F, Freissmuth M, Volkel D, Thiele M, Douillard P, Antoine G, et al.
Mol Cancer Ther
. 2013 Apr;
12(7):1223-34.
PMID: 23619302
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, originally discovered for its eponymous effect and now known for pleiotropic biologic properties in immunology and oncology. Circulating MIF levels are...
7.
An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn
Rao N, Ghosh A, Douillard P, Andoniou C, Zhou P, Band H
Signal Transduct
. 2009 Dec;
2(1-2):29-39.
PMID: 19966925
The Cbl family of ubiquitin ligases function as negative regulators of activated receptor tyrosine kinases by facilitating their ubiquitination and subsequent lysosomal targeting. Here, we have investigated the role of...
8.
Flacher V, Douillard P, Ait-Yahia S, Stoitzner P, Clair-Moninot V, Romani N, et al.
Immunology
. 2008 Jan;
123(3):339-47.
PMID: 18217955
Langerin/CD207 is expressed by a subset of dendritic cells (DC), the epithelial Langerhans cells. However, langerin is also detected among lymphoid tissue DC. Here, we describe striking differences in langerin-expressing...
9.
Reddi A, Ying G, Duan L, Chen G, Dimri M, Douillard P, et al.
J Biol Chem
. 2007 Jul;
282(40):29336-47.
PMID: 17620338
Ubiquitin conjugation to receptor tyrosine kinases is a critical biochemical step in attenuating their signaling through lysosomal degradation. Our previous studies have established Cbl as an E3 ubiquitin ligase for...
10.
Douillard P, Stoitzner P, Tripp C, Clair-Moninot V, Ait-Yahia S, McLellan A, et al.
J Invest Dermatol
. 2005 Nov;
125(5):983-94.
PMID: 16297200
Langerin/CD207 is a C-type lectin associated with formation of Birbeck granules (BG) in Langerhans cells (LC). Here, we describe a monoclonal antibody (mAb 205C1) recognizing the extracellular domain of mouse...