Pasquale Linciano
Overview
Explore the profile of Pasquale Linciano including associated specialties, affiliations and a list of published articles.
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71
Citations
584
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Recent Articles
1.
Listro R, Rossino G, Cavalloro V, Rossi D, Boiocchi M, Robescu M, et al.
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684589
The 1,3-dithiolane ring has been recently rehabilitated as a chemical scaffold in drug design. However, for derivatives that are substituted in position 4, the introduction of a chiral center on...
2.
Gado I, Garbagnoli M, Ambrosio F, Listro R, Parafioriti M, Cauteruccio S, et al.
ACS Omega
. 2024 Nov;
9(45):45147-45158.
PMID: 39554404
Ribonucleic acid (RNA)-binding proteins (RBPs) play a key role in regulating RNA stability, fate, function, gene expression, post-transcriptional modifications, and cellular activities. Among the various RBPs identified to date, the...
3.
Milli G, Pellegrini A, Listro R, Fasolini M, Pagano K, Ragona L, et al.
J Med Chem
. 2024 Oct;
67(20):18139-18156.
PMID: 39384180
Antimicrobial resistance (AMR) represents a critical global health crisis. An innovative strategy to deal with AMR is to interfere with biofilm formation and bacterial quorum sensing (QS). In this study,...
4.
Rossino G, Marrubini G, Brindisi M, Granje M, Linciano P, Rossi D, et al.
Front Chem
. 2024 Jul;
12:1431382.
PMID: 39050371
The Heck reaction is widely employed to build a variety of biologically relevant scaffolds and has been successfully implemented in the production of active pharmaceutical ingredients (APIs). Typically, the reaction...
5.
Garbagnoli M, Linciano P, Listro R, Rossino G, Vasile F, Collina S
ACS Omega
. 2024 Apr;
9(16):17691-17705.
PMID: 38680367
Drug discovery is a lengthy and intricate process, and in its early stage, crucial steps are the selection of the therapeutic target and the identification of novel ligands. Most targets...
6.
Cavalloro V, Marchesi N, Linciano P, Rossi D, Campagnoli L, Fossati A, et al.
Front Pharmacol
. 2024 Feb;
15:1309766.
PMID: 38370479
The number of patients affected by neurodegenerative diseases is increasing worldwide, and no effective treatments have been developed yet. Although precision medicine could represent a powerful tool, it remains a...
7.
Listro R, Marra A, Cavalloro V, Rossino G, Linciano P, Rossi D, et al.
J Pharm Biomed Anal
. 2023 Dec;
239:115902.
PMID: 38101238
The key role of chiral small molecules in drug discovery programs has been deeply investigated throughout last decades. In this context, our previous studies highlighted the influence of the absolute...
8.
Linciano P, Pozzi C, Tassone G, Landi G, Mangani S, Santucci M, et al.
Eur J Med Chem
. 2023 Dec;
264:115946.
PMID: 38043491
Pteridine reductase 1 (PTR1) is a catalytic protein belonging to the folate metabolic pathway in Trypanosmatidic parasites. PTR1 is a known target for the medicinal chemistry development of antiparasitic agents...
9.
Volpe S, Listro R, Ambrosio F, Garbagnoli M, Linciano P, Rossi D, et al.
ACS Med Chem Lett
. 2023 Nov;
14(11):1509-1516.
PMID: 37970588
The RNA binding protein HuR regulates the post-transcriptional process of different oncogenes and tumor suppressor genes, and its dysregulation is linked with cancer. Thus, modulating the complex HuR-RNA represents a...
10.
Linciano P, Quotadamo A, Luciani R, Santucci M, Zorn K, Foil D, et al.
J Med Chem
. 2023 Nov;
66(22):15230-15255.
PMID: 37921561
Broad-spectrum anti-infective chemotherapy agents with activity against , and species were identified from a high-throughput phenotypic screening program of the 456 compounds belonging to the Ty-Box, an in-house industry database....