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Pasi I Nevalainen

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Articles 24
Citations 223
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Recent Articles
1.
Ylanen A, Isojarvi J, Virtanen A, Leijon H, Vesterinen T, Aro A, et al.
Lancet Reg Health Eur . 2025 Feb; 51:101226. PMID: 39995489
Background: Unidentified cardiovascular risk factors may account for approximately half of sudden deaths, a devastating event with limited preventive tools. We investigated whether adrenal histopathology suggestive of primary aldosteronism, pheochromocytoma,...
2.
Koponen L, Pekkinen M, Legebeke J, Muurinen M, Rusanen S, Hussain S, et al.
JBMR Plus . 2025 Jan; 9(2):ziae169. PMID: 39877728
Hypophosphatemic rickets is a rare bone disease characterized by short stature, bone deformities, impaired bone mineralization, and dental problems. Most commonly, hypophosphatemic rickets is caused by pathogenic variants in the...
3.
Ochoa S, Hsu A, Oler A, Kumar D, Chauss D, van Hamburg J, et al.
Sci Transl Med . 2024 Sep; 16(765):eadk0845. PMID: 39292801
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a life-threatening monogenic autoimmune disorder primarily caused by biallelic deleterious variants in the autoimmune regulator () gene. We prospectively evaluated 104 patients with clinically diagnosed...
4.
Kokko E, Viukari M, Koskela J, Choudhary M, Matikainen N, Mustonen J, et al.
Am J Hypertens . 2024 Jul; 37(11):884-892. PMID: 38985455
Background: The incidence of cardiovascular complications may be higher in unilateral than bilateral primary aldosteronism (PA). We compared noninvasive hemodynamics after targeted therapy of bilateral vs. unilateral PA. Methods: Adrenal...
5.
Kokko E, Choudhary M, Mutanen A, Honkonen M, Tikkakoski A, Koskela J, et al.
J Hypertens . 2024 Feb; 42(6):1057-1065. PMID: 38406920
Objectives: We examined haemodynamics, focusing on volume balance and forward and backward wave amplitudes, before and after 2.8 years of targeted treatment of primary aldosteronism. Patients with essential hypertension and...
6.
Choudhary M, Bouquin H, Hytonen J, Koskela J, Niemela O, Nevalainen P, et al.
J Clin Med . 2023 Dec; 12(24). PMID: 38137695
High haemoglobin level has been associated with metabolic syndrome, elevated blood pressure (BP), and increased mortality risk. In this cross-sectional study, we investigated the association of blood haemoglobin with haemodynamics...
7.
Viukari M, Leijon H, Vesterinen T, Soderlund S, Hamalainen P, Yliaska I, et al.
Endocr Connect . 2023 Dec; 13(2). PMID: 38051154
Objective: The associations between adrenal histopathology, lateralization studies, and surgical outcomes in primary aldosteronism remain poorly characterized. We examined the value of immunohistochemical analysis of CYP11B2 for evaluation of adrenalectomy...
8.
Ylanen A, Porsti I, Nevalainen R, Hinkka T, Huhtala H, Matikainen N, et al.
Eur J Endocrinol . 2023 Jul; 188(7):621-629. PMID: 37431563
Background: Screening for primary aldosteronism is based on measuring aldosterone-to-renin ratio. Non-suppressed renin may cause false negative screening results, and such patients may miss focused, potentially curable treatment. We investigated...
9.
Varri E, Suojanen L, Koskela J, Choudhary M, Tikkakoski A, Kahonen M, et al.
Blood Press Monit . 2023 Jun; 28(4):199-207. PMID: 37318783
Objective: To compare blood pressure (BP) in tonometric radial artery recordings during passive head-up tilt with ambulatory recordings and evaluate possible laboratory cutoff values for hypertension. Methods: Laboratory BP and...
10.
Isojarvi J, Viukari M, Porsti I, Leijon H, Vesterinen T, Seppanen M, et al.
Endocrinol Diabetes Metab . 2022 Aug; 5(6):e368. PMID: 36039035
Introduction: Subtype classification method is essential when considering adrenalectomy as a possible treatment for primary aldosteronism. We aimed to retrospectively evaluate surgical outcomes of primary aldosteronism in patients who had...