Pascal Merchiers
Overview
Explore the profile of Pascal Merchiers including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
549
Followers
0
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Recent Articles
1.
Hua Y, Vella G, Rambow F, Allen E, Antoranz Martinez A, Duhamel M, et al.
Cancer Cell
. 2023 Jan;
41(1):226.
PMID: 36626867
No abstract available.
2.
Hua Y, Vella G, Rambow F, Allen E, Antoranz Martinez A, Duhamel M, et al.
Cancer Cell
. 2022 Nov;
40(12):1600-1618.e10.
PMID: 36423635
The lack of T cell infiltrates is a major obstacle to effective immunotherapy in cancer. Conversely, the formation of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs), which are the local site of humoral...
3.
Solomon I, Amann M, Goubier A, Vargas F, Zervas D, Qing C, et al.
Nat Cancer
. 2021 Mar;
1(12):1153-1166.
PMID: 33644766
Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the high affinity receptor subunit for IL-2, is...
4.
Van Damme H, Dombrecht B, Kiss M, Roose H, Allen E, Van Overmeire E, et al.
J Immunother Cancer
. 2021 Feb;
9(2).
PMID: 33589525
Background: Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the...
5.
Maussang D, Mujic-Delic A, Descamps F, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, et al.
J Biol Chem
. 2013 Aug;
288(41):29562-72.
PMID: 23979133
The chemokine receptor CXCR7, belonging to the membrane-bound G protein-coupled receptor superfamily, is expressed in several tumor types. Inhibition of CXCR7 with either small molecules or small interference (si)RNA has...
6.
Emmerson C, van der Vlist E, Braam M, Vanlandschoot P, Merchiers P, De Haard H, et al.
PLoS One
. 2011 Oct;
6(10):e26299.
PMID: 22022593
The polymeric immunoglobulin receptor (pIgR) ensures the transport of dimeric immunoglobulin A (dIgA) and pentameric immunoglobulin M (pIgM) across epithelia to the mucosal layer of for example the intestines and...
7.
Tanghe A, Termont A, Merchiers P, Schilling S, Demuth H, Scrocchi L, et al.
Int J Alzheimers Dis
. 2010 Sep;
2010.
PMID: 20862386
The APP[V717I] London (APP-Ld) mouse model recapitulates important pathological and clinical hallmarks of Alzheimer's disease (AD) and is therefore a valuable paradigm for evaluating therapeutic candidates. Historically, both the parenchymal...
8.
Espuny-Camacho I, Dominguez D, Merchiers P, van Rompaey L, Selkoe D, De Strooper B
J Alzheimers Dis
. 2010 Apr;
20(4):1119-32.
PMID: 20413872
Peroxisome proliferator-activated receptor gamma (PPARgamma) activation results in an increased rate of amyloid-beta (Abeta) clearance from the media of diverse cells in culture, including primary neurons and glial cells. Here,...
9.
Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horre K, et al.
Science
. 2009 Feb;
323(5916):946-51.
PMID: 19213921
Deposition of the amyloid-beta peptide is a pathological hallmark of Alzheimer's disease. A high-throughput functional genomics screen identified G protein-coupled receptor 3 (GPR3), a constitutively active orphan G protein-coupled receptor,...
10.
Camacho I, Serneels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B
J Neurosci
. 2004 Dec;
24(48):10908-17.
PMID: 15574741
We investigated whether peroxisome proliferator-activated receptor gamma (PPARgamma) could be involved in the modulation of the amyloid cascade causing Alzheimer's disease. Inducing expression or activating PPARgamma using synthetic agonists of...