Pascal Chartrand
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Explore the profile of Pascal Chartrand including associated specialties, affiliations and a list of published articles.
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51
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1585
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Recent Articles
1.
Prince S, Maguemoun K, Ferdebouh M, Querido E, Derumier A, Tremblay S, et al.
Nucleic Acids Res
. 2024 Jul;
52(16):9417-9430.
PMID: 39082280
Single-particle imaging and tracking can be combined with colocalization analysis to study the dynamic interactions between macromolecules in living cells. Indeed, single-particle tracking has been extensively used to study protein-DNA...
2.
Bettin N, Querido E, Gialdini I, Grupelli G, Goretti E, Cantarelli M, et al.
Sci Adv
. 2024 Jun;
10(24):eadk4387.
PMID: 38865460
The function of TERRA in the regulation of telomerase in human cells is still debated. While TERRA interacts with telomerase, how it regulates telomerase function remains unknown. Here, we show...
3.
Farajzadeh N, Shahbabian K, Bouaziz Y, Querido E, Chartrand P
RNA
. 2023 Mar;
29(6):745-755.
PMID: 36921931
Messenger RNA (mRNA) localization is an important mechanism controlling local protein synthesis. In budding yeast, asymmetric localization of transcripts such as mRNA to the bud tip depends on the She2...
4.
5.
Smith M, Querido E, Chartrand P, Sfeir A
STAR Protoc
. 2020 Dec;
1(3):100112.
PMID: 33377008
Advances in imaging technologies, gene editing, and fluorescent molecule development have made real-time imaging of nucleic acids practical. Here, we detail methods for imaging the human telomerase RNA template, hTR...
6.
Chartrand P, Sfeir A
Mol Cell Oncol
. 2020 Nov;
7(6):1818537.
PMID: 33241110
Telomerase plays a key role in the immortalization of cancer cells by maintaining telomeres length. Using single-molecule imaging of telomerase RNA molecules in cancer cells, we recently reported novel insights...
7.
Querido E, Sfeir A, Chartrand P
STAR Protoc
. 2020 Oct;
1(2):100104.
PMID: 33111129
Fluorescent hybridization (FISH) on the RNA moiety of human telomerase (hTR) with 50-mer probes detects hTR RNA accumulated in Cajal bodies. Using both live-cell imaging and single-molecule inexpensive FISH, our...
8.
Laprade H, Querido E, Smith M, Guerit D, Crimmins H, Conomos D, et al.
Mol Cell
. 2020 Jun;
79(1):115-126.e6.
PMID: 32497497
Extension of telomeres is a critical step in the immortalization of cancer cells. This complex reaction requires proper spatiotemporal coordination of telomerase and telomeres and remains poorly understood at the...
9.
Chartrand P, Jaramillo M, Gamberi C
Front Genet
. 2020 May;
11:430.
PMID: 32411184
No abstract available.
10.
Lalonde M, Chartrand P
J Mol Biol
. 2020 Feb;
432(15):4232-4243.
PMID: 32084415
In eukaryotes, telomeres are repetitive sequences at the end of chromosomes, which are maintained in a constitutive heterochromatin state. It is now known that telomeres can be actively transcribed, leading...