Parijat Bhatnagar
Overview
Explore the profile of Parijat Bhatnagar including associated specialties, affiliations and a list of published articles.
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15
Citations
96
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Recent Articles
1.
Radhakrishnan H, Newmyer S, Javitz H, Bhatnagar P
Proc Natl Acad Sci U S A
. 2024 Sep;
121(40):e2318687121.
PMID: 39312667
The CD4 T cell, when engineered with a chimeric antigen receptor (CAR) containing specific intracellular domains, has been transformed into a zero-order drug-delivery platform. This introduces the capability of prolonged,...
2.
Radhakrishnan H, Newmyer S, Ssemadaali M, Javitz H, Bhatnagar P
Bioeng Transl Med
. 2024 Jan;
9(1):e10605.
PMID: 38193126
Primary T cell has been transformed into a that synthesizes complex biologics at the disease site with spatiotemporal resolution. This broadly applicable technology can circumvent toxicities due to systemic administration...
3.
Ssemadaali M, Arredondo J, Buser E, Newmyer S, Radhakrishnan H, Javitz H, et al.
Bioeng Transl Med
. 2023 May;
8(3):e10508.
PMID: 37206248
We have developed a serology test platform for identifying individuals with prior exposure to specific viral infections and provide data to help reduce public health risks. The serology test composed...
4.
Newmyer S, Ssemadaali M, Radhakrishnan H, Javitz H, Bhatnagar P
Bioeng Transl Med
. 2023 Mar;
8(2):e10434.
PMID: 36925710
This work reports on an engineered cell that-when electrically stimulated-synthesizes a desired protein, that is, . The platform has been used to express interferon (IFN)-β as a universal antiviral protein....
5.
Ssemadaali M, Newmyer S, Radhakrishnan H, Arredondo J, Javitz H, Dandekar S, et al.
Microbiol Spectr
. 2022 Jul;
10(4):e0073122.
PMID: 35852348
We have engineered a cell that can be used for diagnosing active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Isolation of individuals with active infections offers an effective solution...
6.
Repellin C, Ssemadaali M, Newmyer S, Radhakrishnan H, Javitz H, Bhatnagar P
Adv Biol (Weinh)
. 2021 Apr;
5(7):e2000298.
PMID: 33871182
The NK-92MI, a fast-growing cytolytic cell line with a track record of exerting clinical efficacy, is transformed into a vector for synthesizing calibrated amounts of desired engineered proteins at our...
7.
Radhakrishnan H, Javitz H, Bhatnagar P
Adv Biosyst
. 2020 May;
4(6):e1900288.
PMID: 32390316
A process for maximizing the titer of lentivirus particles, deemed to be a necessity for transducing primary cells, is developed. Lentivirus particles, with a set of transgenes encoding an artificial...
8.
Repellin C, Ganesan P, Alcudia J, Lakshmireddy H, Patel P, Beviglia L, et al.
Adv Biosyst
. 2020 Apr;
4(1):e1900224.
PMID: 32293122
A set of genetically engineered isogenic cell lines is developed to express either folate receptor alpha or mesothelin, and a control cell line negative for both antigens. These cell lines...
9.
Modular Antigen-Specific T-cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins
Repellin C, Patel P, Beviglia L, Javitz H, Sambucetti L, Bhatnagar P
Adv Biosyst
. 2019 Apr;
2(12).
PMID: 30984819
An artificial cell-signaling pathway is developed that capitalizes on the T-cell's innate extravasation ability and transforms it into a vector () for synthesizing calibrated amounts of engineered proteins in vivo....
10.
Bhatnagar P, Alauddin M, Bankson J, Kirui D, Seifi P, Huls H, et al.
Sci Rep
. 2014 Mar;
4:4502.
PMID: 24675806
Genetically-modified T cells expressing chimeric antigen receptors (CAR) exert anti-tumor effect by identifying tumor-associated antigen (TAA), independent of major histocompatibility complex. For maximal efficacy and safety of adoptively transferred cells,...