Parameswaran Ramanathan
Overview
Explore the profile of Parameswaran Ramanathan including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
47
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0
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Recent Articles
1.
Bhimsaria D, Rodriguez-Martinez J, Mendez-Johnson J, Ghoshdastidar D, Varadarajan A, Bansal M, et al.
Nat Commun
. 2023 Jul;
14(1):4179.
PMID: 37443151
Human nuclear receptors (NRs) are a superfamily of ligand-responsive transcription factors that have central roles in cellular function. Their malfunction is linked to numerous diseases, and the ability to modulate...
2.
Kumar P, Adamczyk P, Zhang X, Andrade R, Romero P, Ramanathan P, et al.
Metab Eng
. 2021 Jul;
67:216-226.
PMID: 34229079
In order to make renewable fuels and chemicals from microbes, new methods are required to engineer microbes more intelligently. Computational approaches, to engineer strains for enhanced chemical production typically rely...
3.
Bhimsaria D, Rodriguez-Martinez J, Pan J, Roston D, Korkmaz E, Cui Q, et al.
Proc Natl Acad Sci U S A
. 2018 Oct;
115(45):E10586-E10595.
PMID: 30341220
We have developed Differential Specificity and Energy Landscape (DiSEL) analysis to comprehensively compare DNA-protein interactomes (DPIs) obtained by high-throughput experimental platforms and cutting edge computational methods. While high-affinity DNA binding...
4.
Eguchi A, Wleklinski M, Spurgat M, Heiderscheit E, Kropornicka A, Vu C, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
113(51):E8257-E8266.
PMID: 27930301
Artificial transcription factors (ATFs) are precision-tailored molecules designed to bind DNA and regulate transcription in a preprogrammed manner. Libraries of ATFs enable the high-throughput screening of gene networks that trigger...
5.
Erwin G, Grieshop M, Bhimsaria D, Do T, Rodriguez-Martinez J, Mehta C, et al.
Proc Natl Acad Sci U S A
. 2016 Nov;
113(47):E7418-E7427.
PMID: 27830652
Targeting the genome with sequence-specific DNA-binding molecules is a major goal at the interface of chemistry, biology, and precision medicine. Polyamides, composed of N-methylpyrrole and N-methylimidazole monomers, are a class...