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Charu Mehta

Explore the profile of Charu Mehta including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 187
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Recent Articles
1.
Katsumura K, Liu P, Kim J, Mehta C, Bresnick E
Proc Natl Acad Sci U S A . 2024 Feb; 121(10):e2317147121. PMID: 38422019
Mutations in genes encoding transcription factors inactivate or generate ectopic activities to instigate pathogenesis. By disrupting hematopoietic stem/progenitor cells, GATA2 germline variants create a bone marrow failure and leukemia predisposition,...
2.
Fraga de Andrade I, Johnson K, Mehta C, Dewey C, Basu U, Bresnick E
Blood Adv . 2022 Sep; 7(4):586-601. PMID: 36161469
The RNA-regulatory exosome complex (EC) posttranscriptionally and cotranscriptionally processes and degrades RNAs in a context-dependent manner. Although the EC functions in diverse cell types, its contributions to stem and progenitor...
3.
Mehta C, Fraga de Andrade I, Matson D, Dewey C, Bresnick E
Nucleic Acids Res . 2021 Jun; 49(16):9007-9025. PMID: 34059908
Cellular differentiation requires vast remodeling of transcriptomes, and therefore machinery mediating remodeling controls differentiation. Relative to transcriptional mechanisms governing differentiation, post-transcriptional processes are less well understood. As an important post-transcriptional...
4.
Zwifelhofer N, Cai X, Liao R, Mao B, Conn D, Mehta C, et al.
PLoS Genet . 2020 Dec; 16(12):e1009286. PMID: 33370779
Developmental-regulatory networks often include large gene families encoding mechanistically-related proteins like G-protein-coupled receptors, zinc finger transcription factors and solute carrier (SLC) transporters. In principle, a common mechanism may confer expression...
5.
Fraga de Andrade I, Mehta C, Bresnick E
Nucleic Acids Res . 2020 Oct; 48(21):11913-11928. PMID: 33119769
Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory machinery in controlling differentiation. Dynamic...
6.
You X, Chang Y, Kong G, Ranheim E, Zhou Y, Johnson K, et al.
Leukemia . 2020 Jun; 35(3):901-905. PMID: 32594099
No abstract available.
7.
de Andrade Silva M, Katsumura K, Mehta C, Velloso E, Bresnick E, Godley L
Leukemia . 2020 Apr; 35(1):264-268. PMID: 32286542
No abstract available.
8.
Mehta C, Johnson K, Gao X, Ong I, Katsumura K, McIver S, et al.
Blood . 2020 Jan; 130(Suppl_1):7. PMID: 31940664
No relevant conflicts of interest to declare.
9.
Soukup A, Zheng Y, Mehta C, Wu J, Liu P, Cao M, et al.
J Clin Invest . 2019 Jan; 129(3):1180-1192. PMID: 30620726
The development and function of stem and progenitor cells that produce blood cells are vital in physiology. GATA-binding protein 2 (GATA2) mutations cause GATA-2 deficiency syndrome involving immunodeficiency, myelodysplastic syndrome,...
10.
Bansal P, Verma A, Mehta C, Sangal V
J Environ Manage . 2018 Oct; 233:793-801. PMID: 30309718
In this study, degradation of a pharmaceutical drug, Phenazone (PNZ) has been carried out via heterogeneous photocatalysis, photo-Fenton and in-situ dual process (photocatalysis + photo-Fenton) in suspension and fixed-mode under...