Paolo Innocenti
Overview
Explore the profile of Paolo Innocenti including associated specialties, affiliations and a list of published articles.
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75
Citations
1091
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Recent Articles
1.
The Dual Mode of Antibacterial Action of the Synthetic Small Molecule DCAP Involves Lipid II Binding
Ludwig K, Puls J, Matos de Opitz C, Innocenti P, Daniel J, Bornikoel J, et al.
J Am Chem Soc
. 2024 Aug;
146(36):24855-24862.
PMID: 39197836
The synthetic small molecule DCAP is a chemically well-characterized compound with antibiotic activity against Gram-positive and Gram-negative bacteria, including drug-resistant pathogens. Until now, its mechanism of action was proposed to...
2.
Gao M, Kotsogianni I, Skoulikopoulou F, Bruchle N, Innocenti P, Martin N
ChemMedChem
. 2024 Jul;
19(21):e202400302.
PMID: 38946213
Antibiotics, particularly the β-lactams, are a cornerstone of modern medicine. However, the rise of bacterial resistance to these agents, particularly through the actions of β-lactamases, poses a significant threat to...
3.
Spriano F, Sartori G, Sgrignani J, Barnabei L, Arribas A, Guala M, et al.
Haematologica
. 2024 Jun;
109(11):3602-3614.
PMID: 38899342
Hematologic cancers are among the most common cancers in adults and children. Despite significant improvements in therapies, many patients still succumb to the disease. Therefore, novel therapies are needed. The...
4.
Verschoor J, Croese M, Lakemeier S, Mugge A, Burgers C, Innocenti P, et al.
Commun Biol
. 2024 Jun;
7(1):725.
PMID: 38867087
The rising use of plastic results in an appalling amount of waste which is scattered into the environment. One of these plastics is PET which is mainly used for bottles....
5.
Liu M, Mirza A, McAndrew P, Thapaliya A, Pierrat O, Stubbs M, et al.
J Med Chem
. 2023 Jul;
66(15):10617-10627.
PMID: 37467168
High hit rates from initial ligand-observed NMR screening can make it challenging to prioritize which hits to follow up, especially in cases where there are no available crystal structures of...
6.
Selvaggi F, Cichella A, Aceto G, Innocenti P, Cotellese R
Ann Ital Chir
. 2023 Jan;
93:656-662.
PMID: 36625078
Aim: Black esophagus, or acute esophageal necrosis, is a rare entity with multifactorial aetiology. Modern theories suggest a combination of ischemia, compromised mucosa defences and corrosive agent's injury. Material And...
7.
Slingerland C, Wesseling C, Innocenti P, Westphal K, Masereeuw R, Martin N
J Med Chem
. 2022 Nov;
65(23):15878-15892.
PMID: 36399613
Polymyxins are a class of lipopeptide anti-infective agents with potent and specific activity against Gram-negative bacteria. While toxicity concerns associated with polymyxin B and E (colistin) have historically limited their...
8.
Pierrat O, Liu M, Collie G, Shetty K, Rodrigues M, Le Bihan Y, et al.
Sci Rep
. 2022 Nov;
12(1):18633.
PMID: 36329085
By suppressing gene transcription through the recruitment of corepressor proteins, B-cell lymphoma 6 (BCL6) protein controls a transcriptional network required for the formation and maintenance of B-cell germinal centres. As...
9.
Wade N, Wesseling C, Innocenti P, Slingerland C, Koningstein G, Luirink J, et al.
ACS Infect Dis
. 2022 Nov;
8(11):2242-2252.
PMID: 36318734
In the hunt for new antibiotics with activity against Gram-negative pathogens, the outer membrane β-barrel assembly machine (BAM) complex has become an increasingly interesting target. The recently reported BAM complex...
10.
van Groesen E, Innocenti P, Martin N
ACS Infect Dis
. 2022 Jul;
8(8):1381-1407.
PMID: 35895325
The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to modern medicine's capacity to fight infectious diseases. Gram-positive species such as methicillin-resistant (MRSA) and continue to contribute significantly to...