Pantelis Poumbourios
Overview
Explore the profile of Pantelis Poumbourios including associated specialties, affiliations and a list of published articles.
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39
Citations
965
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Recent Articles
1.
Wilhelm O, Jordan C, Kek H, Brunton-OSullivan M, Rikard-Bell L, Ramanathan P, et al.
J Leukoc Biol
. 2025 Mar;
PMID: 40086815
Enhancement of antibody-dependent cellular cytotoxicity (ADCC) is a promising adjunct approach to achieve HIV control in the absence of antiretroviral therapy but requires the development of potent ADCC-eliciting antibodies which...
2.
Harris A, Kurtovic L, Nogueira J, Bouzas I, Opi D, Wines B, et al.
Commun Med (Lond)
. 2024 Dec;
4(1):273.
PMID: 39702507
Background: SARS-CoV-2 transmission and COVID-19 disease severity is influenced by immunity from natural infection and/or vaccination. Population-level immunity is complicated by the emergence of viral variants. Antibody Fc-dependent effector functions...
3.
Poumbourios P, Langer C, Boo I, Zakir T, Center R, Akerman A, et al.
PLoS Pathog
. 2023 May;
19(5):e1010981.
PMID: 37200378
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates...
4.
Donnison T, McGregor J, Chinnakannan S, Hutchings C, Center R, Poumbourios P, et al.
Hepatology
. 2022 Mar;
76(4):1190-1202.
PMID: 35313015
Background And Aims: A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4 and CD8 T cells...
5.
McGregor J, Hardy J, Lay C, Boo I, Piontek M, Suckow M, et al.
J Virol
. 2022 Jan;
96(5):e0167521.
PMID: 34986001
A vaccine to prevent hepatitis C virus (HCV) infection is urgently needed for use alongside direct-acting antiviral drugs to achieve elimination targets. We have previously shown that a soluble recombinant...
6.
Kek H, Laumaea A, Parise S, Poumbourios P, Hearps A, Jaworowski A
Antiviral Res
. 2021 May;
191:105085.
PMID: 33961905
HIV-infected macrophages contribute to persistence of HIV reservoirs in people living with HIV receiving antiretroviral therapy. A potential strategy to eliminate reservoirs is the use of antibody-dependent cellular cytotoxicity (ADCC)...
7.
Center R, Boo I, Phu L, McGregor J, Poumbourios P, Drummer H
J Biol Chem
. 2020 Apr;
295(21):7179-7192.
PMID: 32299914
The E2 glycoprotein of hepatitis C virus (HCV) is the major target of broadly neutralizing antibodies (bNAbs) that are critical for the efficacy of a prophylactic HCV vaccine. We previously...
8.
Hayward J, Tachedjian M, Kohl C, Johnson A, Dearnley M, Jesaveluk B, et al.
Proc Natl Acad Sci U S A
. 2020 Apr;
117(17):9529-9536.
PMID: 32284399
Bats are reservoirs of emerging viruses that are highly pathogenic to other mammals, including humans. Despite the diversity and abundance of bat viruses, to date they have not been shown...
9.
King H, Gonelli C, Tullett K, Lahoud M, Purcell D, Drummer H, et al.
PLoS One
. 2019 Aug;
14(8):e0220986.
PMID: 31430333
A promising strategy for the enhancement of vaccine-mediated immune responses is by directly targeting protein antigens to immune cells. Targeting of antigens to the dendritic cell (DC) molecule Clec9A has...
10.
Narasimhulu V, Bellamy-McIntyre A, Laumaea A, Lay C, Harrison D, King H, et al.
J Biol Chem
. 2018 Mar;
293(16):6099-6120.
PMID: 29496992
HIV-1 is spread by cell-free virions and by cell-cell viral transfer. We asked whether the structure and function of a broad neutralizing antibody (bNAb) epitope, the membrane-proximal ectodomain region (MPER)...