Pang-Hsien Tu
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Explore the profile of Pang-Hsien Tu including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
1333
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Recent Articles
1.
He R, Lai X, Sun C, Kung T, Hong J, Jheng Y, et al.
Adv Sci (Weinh)
. 2020 Jan;
7(2):1901165.
PMID: 31993280
Finding an effective therapeutic regimen is an urgent demand for various neurodegenerative disorders including Huntington's disease (HD). For the difficulties in observing the dynamic aggregation and oligomerization process of mutant...
2.
Yeh H, Hsu E, Lee S, Lang Y, Lin Y, Chang C, et al.
Nat Cell Biol
. 2018 Mar;
20(4):479-491.
PMID: 29593326
Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is needed to enable targeted intervention. Here, we show that paraspeckle component 1...
3.
Wu H, Lin Y, Liu C, Chung H, Wang Y, Lin Y, et al.
Nat Commun
. 2017 Oct;
8:16167.
PMID: 29035352
This corrects the article DOI: 10.1038/ncomms4214.
4.
Cheng Y, Chen Z, Liao T, Lin C, Shen H, Wang Y, et al.
EMBO Mol Med
. 2017 Mar;
9(5):703-715.
PMID: 28356312
Alzheimer's disease (AD) is the most common neurodegenerative disease. Imbalance between the production and clearance of amyloid β (Aβ) peptides is considered to be the primary mechanism of AD pathogenesis....
5.
Lin C, Cheng Y, Liao T, Lin C, Chen Z, Twu W, et al.
J Alzheimers Dis
. 2016 Jun;
53(3):1053-67.
PMID: 27340844
Amyloid-β (Aβ) aggregation in the brain plays a central and initiatory role in pathogenesis and/or progression of Alzheimer's disease (AD). Inhibiting Aβ aggregation is a potential strategy in the prevention...
6.
Li C, Lin M, Chu S, Tu P, Fang C, Yen C, et al.
Mol Med
. 2014 Dec;
20:684-96.
PMID: 25535034
Glycine N-methyltransferase (GNMT) is known for its function as a tumor suppressor gene. Since 100% of female Gnmt(-/-) mice developed hepatocellular carcinoma, we hypothesized that Gnmt(-/-) mice may have defective...
7.
Shen W, Li H, Chen G, Chern Y, Tu P
Autophagy
. 2014 Dec;
11(4):685-700.
PMID: 25484089
OPTN (optineurin) is an autophagy receptor and mutations in the OPTN gene result in familial glaucoma (E50K) and amyotrophic lateral sclerosis (ALS) (E478G). However, the mechanisms through which mutant OPTN...
8.
Liu Y, Ju T, Chen H, Jang Y, Lee L, Lai H, et al.
Hum Mol Genet
. 2014 Sep;
24(3):787-801.
PMID: 25256353
TAR DNA-binding protein-43 (TDP-43) is a nuclear RNA-binding protein involved in many cellular pathways. TDP-43-positive inclusions are a hallmark of amyotrophic lateral sclerosis (ALS). The major clinical presentation of ALS...
9.
Fang Y, Tsai K, Chang Y, Kao P, Woods R, Kuo P, et al.
Nat Commun
. 2014 Sep;
5:4824.
PMID: 25215604
Proteinaceous inclusions are common hallmarks of many neurodegenerative diseases. TDP-43 proteinopathies, consisting of several neurodegenerative diseases, including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS), are characterized by inclusion...
10.
Liao C, Liou A, Chang Y, Wu S, Chang C, Lee C, et al.
J Virol
. 2014 Aug;
88(21):12485-99.
PMID: 25142603
Unlabelled: Like poliovirus infection, severe infection with enterovirus 71 (EV71) can cause neuropathology. Unlike poliovirus, EV71 is often associated with hand-foot-and-mouth disease (HFMD). Here we established three mouse models for...