Panayiotis E Stevis
Overview
Explore the profile of Panayiotis E Stevis including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
185
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Recent Articles
1.
Zhou Y, Stevis P, Cao J, Ehrlich G, Jones J, Rafique A, et al.
Nat Commun
. 2024 Nov;
15(1):9776.
PMID: 39532904
Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes. While type I...
2.
Zhou Y, Stevis P, Cao J, Saotome K, Wu J, Glatman Zaretsky A, et al.
Sci Adv
. 2023 Mar;
9(11):eade4395.
PMID: 36930708
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles in various cellular processes. We determined cryo-electron microscopy structures...
3.
Okamoto H, Cavino K, Na E, Krumm E, Kim S, Stevis P, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(10):2747-2752.
PMID: 28143927
Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers blood glucose but results in compensatory glucagon hypersecretion involving expansion of pancreatic α-cell mass. Ben-Zvi et al. recently reported that...
4.
Gusarova V, Alexa C, Na E, Stevis P, Xin Y, Bonner-Weir S, et al.
Cell
. 2014 Nov;
159(3):691-6.
PMID: 25417115
Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell proliferation. However, studies of Angptl8(?/?) mice revealed profound reduction of triglyceride...
5.
Chengalvala M, Chennathukuzhi V, Johnston D, Stevis P, Kopf G
Curr Genomics
. 2008 Jul;
8(4):262-70.
PMID: 18645595
The availability of sequenced genomes of human and many experimental animals necessitated the development of new technologies and powerful computational tools that are capable of exploiting these genomic data and...
6.
Arey B, Yanofsky S, Perez M, Holmes C, Wrobel J, Gopalsamy A, et al.
Biochem Biophys Res Commun
. 2008 Feb;
368(3):723-8.
PMID: 18252197
The follicle-stimulating hormone is critical to reproductive success and is an important target for development of novel reproductive therapies. We have recently reported the development of thiazolidinone positive allosteric modulators...
7.
Stevis P, Deecher D
Anal Biochem
. 2005 Mar;
338(2):320-5.
PMID: 15745753
The receptors for the glycoprotein hormones are unique in having a large extracellular domain that is responsible for mediating ligand binding. We describe the characterization, validation, and application of a...
8.
Stevis P, Arey B, Deecher D
Biochem Biophys Res Commun
. 2004 Jun;
319(3):1026-31.
PMID: 15184084
The glycoprotein hormones are heterodimeric proteins that share a common alpha subunit and have unique beta subunits that confer receptor selectivity. One member of this family, follicle-stimulating hormone (FSH), is...
9.
Arey B, Deecher D, Shen E, Stevis P, Meade Jr E, Wrobel J, et al.
Endocrinology
. 2002 Sep;
143(10):3822-9.
PMID: 12239093
The glycoprotein hormones (LH, FSH, and TSH) are critical to the maintenance of physiological homeostasis and control of reproduction. However, despite an obvious utility for synthetic pharmacological agents, there are...