Panagiota N Mitrou
Overview
Explore the profile of Panagiota N Mitrou including associated specialties, affiliations and a list of published articles.
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19
Citations
841
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0
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Recent Articles
1.
Gay L, Mitrou P, Keen J, Bowman R, Naguib A, Cooke J, et al.
J Pathol
. 2012 Aug;
228(3):405-15.
PMID: 22864938
The tumour suppressor APC is the most commonly altered gene in colorectal cancer (CRC). Genetic and epigenetic alterations of APC may therefore be associated with dietary and lifestyle risk factors...
2.
Gay L, Arends M, Mitrou P, Bowman R, Ibrahim A, Happerfield L, et al.
Nutr Cancer
. 2011 Aug;
63(7):1000-10.
PMID: 21875327
There is conflicting evidence for the role diet and lifestyle play in the development of mismatch repair (MMR)-deficient colorectal cancers (CRC). In this study, associations between MMR deficiency, clinicopathological characteristics,...
3.
Naguib A, Cooke J, Happerfield L, Kerr L, Gay L, Luben R, et al.
BMC Cancer
. 2011 Apr;
11:123.
PMID: 21473780
Background: The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence...
4.
Loh Y, Jakszyn P, Luben R, Mulligan A, Mitrou P, Khaw K
Am J Clin Nutr
. 2011 Mar;
93(5):1053-61.
PMID: 21430112
Background: Humans are exposed to preformed N-nitroso compounds (NOCs) and endogenous NOCs. Several NOCs are potential human carcinogens, including N-nitrosodimethylamine (NDMA), but evidence from population studies is inconsistent. Objective: We...
5.
Loh Y, Mitrou P, Wood A, Luben R, McTaggart A, Khaw K, et al.
Cancer Epidemiol
. 2010 Nov;
35(4):369-74.
PMID: 21075068
Purpose: The SMAD7 gene was recently identified to be associated with colorectal cancer risk. Smad7 protein is a known inhibitor of TGF-β signalling pathway which has a prominent role in...
6.
Naguib A, Mitrou P, Gay L, Cooke J, Luben R, Ball R, et al.
BMC Cancer
. 2010 Mar;
10:99.
PMID: 20233436
Background: BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and...
7.
Park J, Mitrou P, Keen J, Dahm C, Gay L, Luben R, et al.
Mutagenesis
. 2010 Mar;
25(4):351-8.
PMID: 20228093
The tumour suppressor p53 is one of the most commonly altered genes in colorectal cancer (CRC) development. Genetic alterations in p53 may therefore be associated with postulated lifestyle risk factors...
8.
Loh Y, Mitrou P, Bowman R, Wood A, Jeffery H, Luben R, et al.
DNA Repair (Amst)
. 2010 Jan;
9(4):421-8.
PMID: 20096652
O(6)-Methylguanine-DNA methyltransferase (MGMT) repairs DNA damage caused by alkylating agents including N-nitroso compounds from diet. MGMT Ile143Val polymorphism may lead to less DNA damage repair and increased cancer risk depending...
9.
Reedy J, Wirfalt E, Flood A, Mitrou P, Krebs-Smith S, Kipnis V, et al.
Am J Epidemiol
. 2009 Dec;
171(4):479-87.
PMID: 20026579
The authors compared dietary pattern methods-cluster analysis, factor analysis, and index analysis-with colorectal cancer risk in the National Institutes of Health (NIH)-AARP Diet and Health Study (n = 492,306). Data...
10.
Park J, Mitrou P, Dahm C, Luben R, Wareham N, Khaw K, et al.
Cancer Epidemiol
. 2009 Nov;
33(5):347-54.
PMID: 19932648
Excessive alcohol consumption has been associated with increased risk of colorectal cancer (CRC). However, the effect of modest alcohol consumption or of particular types of beverages on CRC risk remains...